Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Automatic assignment of GO terms using logical inference, based on on inter-ontology links

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

Three proteins define a class of human histone deacetylases related to yeast Hda1p.

Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain.

Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family.

HDAC6 is a microtubule-associated deacetylase.

Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes.

Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms.

The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase.

The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress.

HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor.

HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin.

Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperone.

HEF1-dependent Aurora A activation induces disassembly of the primary cilium.

HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates.

Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion.

Selective inhibition of histone deacetylase 2 silences progesterone receptor-mediated signaling.

HDAC6 is required for epidermal growth factor-induced beta-catenin nuclear localization.

HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation.

Histone deacetylase 6 interacts with the microtubule-associated protein tau.

Genistein down-regulates androgen receptor by modulating HDAC6-Hsp90 chaperone function.

The ubiquitin-like modifier FAT10 interacts with HDAC6 and localizes to aggresomes under proteasome inhibition.

Direct binding with histone deacetylase 6 mediates the reversible recruitment of parkin to the centrosome.

A BBSome subunit links ciliogenesis, microtubule stability, and acetylation.

A centrosomal Cdc20-APC pathway controls dendrite morphogenesis in postmitotic neurons.

The protein farnesyltransferase regulates HDAC6 activity in a microtubule-dependent manner.

Tau--an inhibitor of deacetylase HDAC6 function.

CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin.

Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6.

TPPP/p25 promotes tubulin acetylation by inhibiting histone deacetylase 6.

Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy.

Regulation of Tat acetylation and transactivation activity by the microtubule-associated deacetylase HDAC6.

The HTLV-1 Tax protein inhibits formation of stress granules by interacting with histone deacetylase 6.

Parkin interacts with Ambra1 to induce mitophagy.

Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin.

PKC alpha regulates Sendai virus-mediated interferon induction through HDAC6 and β-catenin.

A novel GRK2/HDAC6 interaction modulates cell spreading and motility.

Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicity.

Regulation of CD133 by HDAC6 promotes β-catenin signaling to suppress cancer cell differentiation.

Rho-associated coiled-coil kinase (ROCK) protein controls microtubule dynamics in a novel signaling pathway that regulates cell migration.

A novel small molecule hydroxamate preferentially inhibits HDAC6 activity and tumour growth.

HDAC6 regulates mutant SOD1 aggregation through two SMIR motifs and tubulin acetylation.

Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance.

Differential regulation of estrogen receptor α expression in breast cancer cells by metastasis-associated protein 1.

The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.

Fam65b is important for formation of the HDAC6-dysferlin protein complex during myogenic cell differentiation.

Disruption of FAT10-MAD2 binding inhibits tumor progression.

ATP13A2 and Alpha-synuclein: a Metal Taste in Autophagy.

Deacetylation of α-tubulin and cortactin is required for HDAC6 to trigger ciliary disassembly.

FAM65B controls the proliferation of transformed and primary T cells.

HDAC6 Inhibitors Rescued the Defective Axonal Mitochondrial Movement in Motor Neurons Derived from the Induced Pluripotent Stem Cells of Peripheral Neuropathy Patients with HSPB1 Mutation.

Roles of tau protein in health and disease.

Histone deacetylase 10 structure and molecular function as a polyamine deacetylase.

HDAC6 controls innate immune and autophagy responses to TLR-mediated signalling by the intracellular bacteria Listeria monocytogenes.

Requirement for p62 acetylation in the aggregation of ubiquitylated proteins under nutrient stress.

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).

Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

HSF1 activation

Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates

HDAC6 deacetylates microtubules

Cargo trafficking to the periciliary membrane

PolyUb-Misfolded Proteins:HDAC6 bind dynein motor

PolyUb-Misfolded proteins bind vimentin to form aggresome

Aggresome dissociates from dynein and microtubule

Deep research report on HDAC6