FUNDC1 notes

Deep research was not run: falcon times out in this environment and perplexity-lite is not installed. These notes are based on the cached publications and the UniProt record.

Core biology

• An integral mitochondrial outer-membrane receptor for hypoxia-induced mitophagy PMID:22267086
• Binds LC3 through an N-terminal LIR, which is required for mitophagy PMID:22267086
• Regulated by phosphorylation: ULK1 phosphorylates Ser17 PMID:24671035
• Acts as a DRP1 adaptor at MAMs PMID:27145933, and is stabilized there by USP19 PMID:33978709.

Curation decisions

• Protein binding rows with LC3 partners from PMID:22267086 were changed (MODIFY) to GO:0140580. All other protein binding rows were removed.
• The mitochondrial fusion IGI (PMID:37931419, abstract only) was left UNDECIDED, because the abstract describes Drp1-dependent fission.
• Three NEW annotations: GO:0090141 positive regulation of mitochondrial fission, GO:0044233 MAM contact site, and GO:0043495 protein-membrane adaptor activity, all from PMID:27145933 and PMID:33978709.