GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
PMID:15502827
X-linked inheritance of Fanconi anemia complementation group B.
PMID:16116422
A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M.
PMID:17396147
FAAP100 is essential for activation of the Fanconi anemia-associated DNA damage response pathway.
PMID:19965384
The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair.
PMID:20347428
A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability.
PMID:21458466
The phenotype of FancB-mutant mouse embryonic stem cells.
PMID:22343915
FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathway.
PMID:27986592
The FA Core Complex Contains a Homo-dimeric Catalytic Module for the Symmetric Mono-ubiquitination of FANCI-FANCD2.
PMID:31666700
Structure of the Fanconi anaemia monoubiquitin ligase complex.
PMID:32106311
Association of clinical severity with FANCB variant type in Fanconi anemia.
PMID:32939280
Deep learning enables the atomic structure determination of the Fanconi Anemia core complex from cryoEM.
Reactome:R-HSA-6785126
FA core complex assembles at DNA interstrand crosslinks (ICLs)
Reactome:R-HSA-6785342
FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex
Reactome:R-HSA-6785361
Monoubiquitination of FANCD2:FANCI
Reactome:R-HSA-6785732
DNA nucleases bind monoubiquitinated ID2 complex
Reactome:R-HSA-6785986
DNA nucleases unhook the interstrand crosslink (ICL)
Reactome:R-HSA-6786155
POLN binds ICL-DNA
Reactome:R-HSA-6786166
Translesion synthesis across unhooked ICL by POLN
Reactome:R-HSA-6786171
FANCD2 deubiquitination by USP1:WDR48
Reactome:R-HSA-6788385
The complex of ATR and ATRIP is recruited to ICL-DNA
Reactome:R-HSA-6788392
ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA
Reactome:R-HSA-9835411
FA core complex:HSP70s binds PKR