Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Combined Automated Annotation using Multiple IEA Methods
Notch signalling controls pancreatic cell differentiation.
Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2.
p48 subunit of mouse PTF1 binds to RBP-Jkappa/CBF-1, the intracellular mediator of Notch signalling, and is expressed in the neural tube of early stage embryos.
HERP1 is a cell type-specific primary target of Notch.
Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells.
Notch signaling regulates left-right asymmetry determination by inducing Nodal expression.
Notch-regulated ankyrin-repeat protein inhibits Notch1 signaling: multiple Notch1 signaling pathways involved in T cell development.
Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation.
Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants.
Fibroblast growth factor receptor signaling promotes radial glial identity and interacts with Notch1 signaling in telencephalic progenitors.
RBPjkappa-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells.
RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes.
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In the absence of Notch, RBP-J represses via SHARP/CtIP/CtBP corepressors.
"In the absence of Notch, RBP-Jkappa represses Notch target genes through the recruitment of a corepressor complex."
Sustained Notch signaling in progenitors is required for sequential emergence of distinct cell lineages during organogenesis.
Canonical notch signaling functions as a commitment switch in the epidermal lineage.
Baf60c is a nuclear Notch signaling component required for the establishment of left-right asymmetry.
Rbm15 modulates Notch-induced transcriptional activation and affects myeloid differentiation.
Notch signaling is essential for ventricular chamber development.
Opposing LSD1 complexes function in developmental gene activation and repression programmes.
Notch directly regulates Gata3 expression during T helper 2 cell differentiation.
Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch.
Monitoring Notch1 activity in development: evidence for a feedback regulatory loop.
Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex.
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RBPJ is part of the PTF1-J trimeric complex with Ptf1a in early pancreas (Notch-independent).
"active PTF1a requires interaction with RBPJ, the vertebrate Suppressor of Hairless, within a stable trimeric DNA-binding complex (PTF1)."
RAM-induced allostery facilitates assembly of a notch pathway active transcription complex.
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RAM binding induces allosteric change in CSL creating a Mastermind docking site.
"Our structural studies reveal a striking distal conformational change in CSL upon RAM binding, which creates a docking site for Mastermind to bind to the complex."
Slug is a direct Notch target required for initiation of cardiac cushion cellularization.
Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity.
Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti.
Notch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somites.
Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation.
Differential Notch signaling in the epicardium is required for cardiac inflow development and coronary vessel morphogenesis.
Notch signaling in stomach epithelial stem cell homeostasis.
Diet-induced aortic valve disease in mice haploinsufficient for the Notch pathway effector RBPJK/CSL.
Pten coordinates retinal neurogenesis by regulating Notch signalling.
Wnt/β-catenin and Bmp signals control distinct sets of transcription factors in cardiac progenitor cells.
Neuroepithelial body microenvironment is a niche for a distinct subset of Clara-like precursors in the developing airways.
Transcriptome analysis for Notch3 target genes identifies Grip2 as a novel regulator of myogenic response in the cerebrovasculature.
BEND6 is a nuclear antagonist of Notch signaling during self-renewal of neural stem cells.
Prdm13 mediates the balance of inhibitory and excitatory neurons in somatosensory circuits.
Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens.
Structure and function of the CSL-KyoT2 corepressor complex: a negative regulator of Notch signaling.
Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity.
RBPJ in mouse Sertoli cells is required for proper regulation of the testis stem cell niche.
Notch-Tnf signalling is required for development and homeostasis of arterial valves.
RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1.
Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H).
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RBP-J binds the CGTGGGAA motif and directly binds the Notch1 RAM domain.
"RBP-J kappa and Su(H) bind directly to the RAM23 regions of mouse Notch1 and Drosophila Notch, respectively."
Conservation of the Notch signalling pathway in mammalian neurogenesis.
RBP-L, a transcription factor related to RBP-Jkappa.
Notch2 and phosphorylated Creb1 bind Gzmb promoter
Notch2 binds Hes1 promoter
Notch2 binds Hes5 promoter
mNOTCH1 coactivator complex bind promoters of Hey genes
Notch3 coactivator complex binds the Ptcra gene promoter
Notch3 coactivator complex binds the Heyl gene promoter
Lef1:Ctnnb1, Nicd (Notch), and Tbx6 bind the Hes7 gene in presomitic mesoderm
Rbpj:Nicd and Msgn1 bind the Lfng gene
Stat6, Nfatc2 (Nfat1), and Nicd1,2 bind the Gata3 gene and cause displacement of repressor complexes (Prc1, Rbpj:NcoR) by activator complexes (Mll1, Rbpj:Nicd1,2)