Delta proteins and MAGI proteins: an interaction of Notch ligands with intracellular scaffolding molecules and its significance for zebrafish development.
Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Combined Automated Annotation using Multiple IEA Methods
Expression of the mouse Delta1 gene during organogenesis and fetal development.
Expression of Delta1 and Serrate1 (Jagged1) in the mouse inner ear.
Notch signalling controls pancreatic cell differentiation.
Notch signalling is required for cyclic expression of the hairy-like gene HES1 in the presomitic mesoderm.
Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2.
-
Delta1 binds Notch2 and induces its cleavage, nuclear translocation and RBP-J reporter activity.
"binding of DSL proteins to Notch2 also activated the transcription of reporter genes driven by the RBP-Jkappa-responsive promoter."
Oscillating expression of c-Hey2 in the presomitic mesoderm suggests that the segmentation clock may use combinatorial signaling through multiple interacting bHLH factors.
Segmentation defects of Notch pathway mutants and absence of a synergistic phenotype in lunatic fringe/radical fringe double mutant mice.
Notch signaling regulates left-right asymmetry determination by inducing Nodal expression.
The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase.
-
Dll1 undergoes ADAM10 shedding then gamma-secretase cleavage.
"Kuzbanian/ADAM10 is involved in this processing event, but other proteases can probably substitute for it."
Interaction of the MAGUK family member Acvrinp1 and the cytoplasmic domain of the Notch ligand Delta1.
Specification of vertebral identity is coupled to Notch signalling and the segmentation clock.
Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo.
Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1.
The extracellular matrix protein MAGP-2 interacts with Jagged1 and induces its shedding from the cell surface.
Segmental expression of Notch and Hairy genes in nephrogenesis.
The Mesp2 transcription factor establishes segmental borders by suppressing Notch activity.
MAGI1 recruits Dll1 to cadherin-based adherens junctions and stabilizes it on the cell surface.
Mind bomb 1 is essential for generating functional Notch ligands to activate Notch.
Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear.
Notch signaling requires GATA-2 to inhibit myelopoiesis from embryonic stem cells and primary hemopoietic progenitors.
Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1.
Premature myogenic differentiation and depletion of progenitor cells cause severe muscle hypotrophy in Delta1 mutants.
Role of the Notch ligand Delta1 in embryonic and adult mouse epidermis.
MicroRNA regulation of cell lineages in mouse and human embryonic stem cells.
The intracellular region of Notch ligands Dll1 and Dll3 regulates their trafficking and signaling activity.
-
Dll1 ubiquitination is required for recycling and Notch affinity.
"ubiquitination, although not required for endocytosis, is essential for Dll1 recycling and that recycling is required to acquire affinity for the receptor."
Selection of differentiating cells by different levels of delta-like 1 among neural precursor cells in the developing mouse telencephalon.
DLL1-mediated Notch activation regulates endothelial identity in mouse fetal arteries.
Lunatic and manic fringe cooperatively enhance marginal zone B cell precursor competition for delta-like 1 in splenic endothelial niches.
Dll1 and Dll4 function sequentially in the retina and pV2 domain of the spinal cord to regulate neurogenesis and create cell diversity.
Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes.
Neuralized-2: expression in human and rodents and interaction with Delta-like ligands.
Domain-specific control of neurogenesis achieved through patterned regulation of Notch ligand expression.
Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells.
MT1-MMP cleaves Dll1 to negatively regulate Notch signalling to maintain normal B-cell development.
Delta1 expression, cell cycle exit, and commitment to a specific secretory fate coincide within a few hours in the mouse intestinal stem cell system.
Delta-like 1-Lysine613 regulates notch signaling.
Ptf1a-mediated control of Dll1 reveals an alternative to the lateral inhibition mechanism.
Extrinsic Notch ligand Delta-like 1 regulates tip cell selection and vascular branching morphogenesis.
Mind bomb 1 is required for pancreatic β-cell formation.
Colonization of the satellite cell niche by skeletal muscle progenitor cells depends on Notch signals.
Lfng regulates the synchronized oscillation of the mouse segmentation clock via trans-repression of Notch signalling.
Delta-like 1 regulates Bergmann glial monolayer formation during cerebellar development.
Dll1 maintains quiescence of adult neural stem cells and segregates asymmetrically during mitosis.
The extracellular domain of Notch2 increases its cell-surface abundance and ligand responsiveness during kidney development.
Synaptojanin-2 binding protein stabilizes the Notch ligands DLL1 and DLL4 and inhibits sprouting angiogenesis.
Cadherin-based adhesions in the apical endfoot are required for active Notch signaling to control neurogenesis in vertebrates.
Divergent and conserved roles of Dll1 signaling in development of craniofacial and trunk muscle.
Context-Dependent Functional Divergence of the Notch Ligands DLL1 and DLL4 In Vivo.
Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear.
Delta-notch signaling in odontogenesis: correlation with cytodifferentiation and evidence for feedback regulation.
Dll1 gene expression is inhibited by Mecp2
Expression of Dll1 in paraxial mesoderm
Expression of Dll1 in presomitic mesoderm
Expression of Dll1 during nephron development