Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Role of a class DHC1b dynein in retrograde transport of IFT motors and IFT raft particles along cilia, but not dendrites, in chemosensory neurons of living Caenorhabditis elegans.
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CHE-3 is the C. elegans ortholog of Chlamydomonas DHC1b
"The Chlamydomonas DHC1b polypeptide shares high homology with the C. elegans CHE-3 protein"
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CHE-3 drives retrograde transport specifically in cilia, not dendrites
"Thus, we propose that the class DHC1b cytoplasmic dynein, CHE-3, is specifically responsible for the retrograde transport of the anterograde motor, kinesin-II, and its cargo within sensory cilia, but not within dendrites."
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che-3 mutants show complete loss of retrograde IFT with accumulation of cargo at cilium tips
"Strikingly, over many hours of observation, we never saw retrograde IFT in cilia of che-3 mutants, in contrast to the robust transport that we consistently observed in wild-type worms."
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Anterograde IFT is unaffected in che-3 mutants
"In contrast, anterograde IFT proceeds normally in che-3 mutants."
CHE-3, a cytosolic dynein heavy chain, is required for sensory cilia structure and function in Caenorhabditis elegans.
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CHE-3 is the DHC1b isoform expressed specifically in ciliated sensory neurons
"This isoform of dynein shows temporally and spatially restricted expression in ciliated sensory neurons"
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che-3 mutants have progressive developmental defects of chemosensory cilia
"mutants show progressive developmental defects of the chemosensory cilia"
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CHE-3 is required for intraflagellar transport and cilium structural integrity
"These results are consistent with a role for this motor protein in the process of intraflagellar transport"
The C. elegans homolog of the murine cystic kidney disease gene Tg737 functions in a ciliogenic pathway and is disrupted in osm-5 mutant worms.
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OSM-5 is part of the conserved IFT process
"Overall, the data support a crucial role for osm-5 in a conserved ciliogenic pathway, most likely as a component of the IFT process."
DAF-7/TGF-beta expression required for the normal larval development in C. elegans is controlled by a presumed guanylyl cyclase DAF-11.
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Cilium-related genes che-2 and che-3 are genetically placed in the dauer signaling pathway
"cilium-related genes che-2 and che-3 are placed between daf-11 and daf-7, in the genetic pathway controlling dauer formation"
Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans.
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che-3 is among nine genes causing structurally defective chemosensory cilia
"Dauer-defective mutations in nine genes cause structurally defective chemosensory cilia, thereby blocking chemosensation."
A pheromone-induced developmental switch in Caenorhabditis elegans - Temperature-sensitive mutants reveal a wild-type temperature-dependent process.
Dynein-Driven Retrograde Intraflagellar Transport Is Triphasic in C. elegans Sensory Cilia.
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Cytoplasmic dynein-2 powers retrograde IFT essential for cilium formation and maintenance
"Cytoplasmic dynein-2 powers retrograde intraflagellar transport that is essential for cilium formation and maintenance."
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Ciliopathy-related mutations in dynein-2 heavy chain reduce transport speed and frequency
"By knocking the conserved ciliopathy-related mutations into the C. elegans dynein-2 heavy chain, we find that these mutations reduce its transport speed and frequency."
Deep research report on che-3