Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Combined Automated Annotation using Multiple IEA Methods
The candidate gene for the X-linked Kallmann syndrome encodes a protein related to adhesion molecules.
A gene deleted in Kallmann's syndrome shares homology with neural cell adhesion and axonal path-finding molecules.
Novel mechanisms of fibroblast growth factor receptor 1 regulation by extracellular matrix protein anosmin-1.
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Anosmin-1 directly binds FGFR1 and displays receptor-selective affinity.
"anosmin-1 binds to FGFR2IIIc with much lower affinity and displays negligible
binding to FGFR3IIIc."
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Heparin-bound anosmin-1 joins a preformed FGF2–FGFR1 complex.
"By contrast, heparin-bound anosmin-1 binds
to pre-formed FGF2.FGFR1 complex, generating an anosmin-1.FGFR1.FGF2.heparin
complex."
A reference map of the human binary protein interactome.
Comprehensive analysis of anosmin-1 as a potential biomarker and its correlation with epithelial-mesenchymal transition in advanced gastric cancer.
The Kallmann syndrome gene product expressed in COS cells is cleaved on the cell surface to yield a diffusible component.
Cross-talk of anosmin-1, the protein implicated in X-linked Kallmann's syndrome, with heparan sulphate and urokinase-type plasminogen activator.
Anosmin-1 modulates fibroblast growth factor receptor 1 signaling in human gonadotropin-releasing hormone olfactory neuroblasts through a heparan sulfate-dependent mechanism.
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Human embryonic olfactory neuroblasts show an anosmin-1-dependent neurite response.
"In human embryonic GnRH olfactory neuroblasts, wild-type anosmin-1, but not
proteins with loss-of-function KS mutations, induces neurite outgrowth"
Anosmin-1 underlying the X chromosome-linked Kallmann syndrome is an adhesion molecule that can modulate neurite growth in a cell-type specific manner.
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Cell adhesion depends on cell-surface sulfated glycosaminoglycans.
"cell adhesion to anosmin-1 is dependent on the presence of
heparan sulfate and chondroitin sulfate glycosaminoglycans at the cell surface."
Anosmin-1, defective in the X-linked form of Kallmann syndrome, promotes axonal branch formation from olfactory bulb output neurons.
Anosmin-1 is a regionally restricted component of basement membranes and interstitial matrices during organogenesis: implications for the developmental anomalies of X chromosome-linked Kallmann syndrome.
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Human localization studies identify anosmin-1 in basement membranes and interstitial matrices.
"component of extracellular matrices during organogenesis in man. Anosmin-1 was
detected in the basement membranes and/or interstitial matrices"
ANOS1 primary-source assessment and annotation review notes