FOX2 (YKR009C; MFE-2; UniProt Q02207) notes

• Multifunctional enzyme type 2: 2-enoyl-CoA hydratase 2 + D-(3R)-3-hydroxyacyl-CoA dehydrogenase; lacks crotonase, L-(3S)-dehydrogenase and epimerase PMID:1551874.
• Yeast beta-oxidation goes via the (3R) intermediate PMID:1551874.
• Two SDR dehydrogenase domains A (medium/long chain) and B (short chain); inactivating both abolishes growth on oleate PMID:10497229.
• C-terminal MaoC-like hydratase 2 domain; EC 4.2.1.119 and 1.1.1.n12 [UniProt:Q02207].
• Peroxisomal; PTS1 plus Pex5p-dependent PTS1-independent import, weak Pex9p import PMID:30131444.

Pathway-context observations (important for module curator)

• YeastPathways context gives EC 4.2.1.17 (S-hydratase) and EC 1.1.1.35 ((3S)-dehydrogenase). These are the wrong stereochemistry for S. cerevisiae: the correct activities are EC 4.2.1.119 (GO:0080023) and (3R)-3-hydroxyacyl-CoA dehydrogenase (GO:0106386).
• The IDA GO:0003857 from PMID:1551874 contradicts its own abstract; reviewed MODIFY -> GO:0106386. IBA node PTN002894972 is seeded only by FOX2 itself, so it inherits the same error.
• PWY-5177 RCA rows (dehydratase, (3S)-dehydrogenase, carboxylic acid catabolism, cytosol) come from a non-beta-oxidation YeastCyc pathway with no yeast evidence for FOX2 involvement.