Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

RGD ISO annotations to rat from other mammalian species

Functional and biochemical analysis of the C2 domains of synaptotagmin IV.

Direct interaction between synaptotagmin and the intracellular loop I-II of neuronal voltage-sensitive sodium channels.

Nadrin, a novel neuron-specific GTPase-activating protein involved in regulated exocytosis.

Human stoned B interacts with AP-2 and synaptotagmin and facilitates clathrin-coated vesicle uncoating.

The AP2 binding site of synaptotagmin 1 is not an internalization signal but a regulator of endocytosis.

Synaptotagmin IX regulates Ca2+-dependent secretion in PC12 cells.

C2A activates a cryptic Ca(2+)-triggered membrane penetration activity within the C2B domain of synaptotagmin I.

Sr2+ binding to the Ca2+ binding site of the synaptotagmin 1 C2B domain triggers fast exocytosis without stimulating SNARE interactions.

Identification of synaptotagmin effectors via acute inhibition of secretion from cracked PC12 cells.

N-glycosylation is essential for vesicular targeting of synaptotagmin 1.

RNA interference-mediated silencing of synaptotagmin IX, but not synaptotagmin I, inhibits dense-core vesicle exocytosis in PC12 cells.

Crystallographic identification of Ca2+ and Sr2+ coordination sites in synaptotagmin I C2B domain.

Synaptotagmin: a calcium sensor on the synaptic vesicle surface.

Synaptotagmin-12, a synaptic vesicle phosphoprotein that modulates spontaneous neurotransmitter release.

Synaptotagmin I and IX function redundantly in controlling fusion pore of large dense core vesicles.

JNK phosphorylates synaptotagmin-4 and enhances Ca2+-evoked release.

Molecular basis of synaptic vesicle cargo recognition by the endocytic sorting adaptor stonin 2.

Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders.

Analysis of the synaptotagmin family during reconstituted membrane fusion. Uncovering a class of inhibitory isoforms.

Direct interaction of SNARE complex binding protein synaphin/complexin with calcium sensor synaptotagmin 1.

Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation.

Single-molecule FRET-derived model of the synaptotagmin 1-SNARE fusion complex.

Rat and Drosophila synaptotagmin 4 have opposite effects during SNARE-catalyzed membrane fusion.

Release mode of large and small dense-core vesicles specified by different synaptotagmin isoforms in PC12 cells.

Synaptotagmin 1 modulates lipid acyl chain order in lipid bilayers by demixing phosphatidylserine.

The importance of an asymmetric distribution of acidic lipids for synaptotagmin 1 function as a Ca2+ sensor.

Subcellular localization and putative role of VPS13A/chorein in dopaminergic neuronal cells.

Phosphatidylinositol 4,5-bisphosphate increases Ca2+ affinity of synaptotagmin-1 by 40-fold.

Cis- and trans-membrane interactions of synaptotagmin-1.

SNAREpin assembly by Munc18-1 requires previous vesicle docking by synaptotagmin 1.

Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C.

Rapid fusion of synaptic vesicles with reconstituted target SNARE membranes.

A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis.

The synaptotagmin 1 linker may function as an electrostatic zipper that opens for docking but closes for fusion pore opening.

Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.

The juxtamembrane linker of full-length synaptotagmin 1 controls oligomerization and calcium-dependent membrane binding.

Identification of a human synaptotagmin-1 mutation that perturbs synaptic vesicle cycling.

The juxtamembrane region of synaptotagmin 1 interacts with dynamin 1 and regulates vesicle fission during compensatory endocytosis in endocrine cells.

Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis.

Synaptotagmin-1 and -7 Are Redundantly Essential for Maintaining the Capacity of the Readily-Releasable Pool of Synaptic Vesicles.

Synaptotagmin-1 C2B domain interacts simultaneously with SNAREs and membranes to promote membrane fusion.

Localization of Rab3A-binding site on C2A domain of synaptotagmin I to reveal its regulatory mechanism.

Rab3A Inhibition of Ca(2+) -Dependent Dopamine Release From PC12 Cells Involves Interaction With Synaptotagmin I.

The calcium sensor synaptotagmin 1 is expressed and regulated in hippocampal postsynaptic spines.

Synaptotagmin-1-, Munc18-1-, and Munc13-1-dependent liposome fusion with a few neuronal SNAREs.

Polybasic Patches in Both C2 Domains of Synaptotagmin-1 Are Required for Evoked Neurotransmitter Release.

Synaptotagmin 1-mediated cell membrane penetration and dopamine release enhancement by latroeggtoxin-VI.

The juxtamembrane linker of synaptotagmin 1 regulates Ca(2+) binding via liquid-liquid phase separation.

Identification of a synaptic vesicle-specific membrane protein with a wide distribution in neuronal and neurosecretory tissue.

Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins.

A single C2 domain from synaptotagmin I is sufficient for high affinity Ca2+/phospholipid binding.

The V0 sector of the V-ATPase, synaptobrevin, and synaptophysin are associated on synaptic vesicles in a Triton X-100-resistant, freeze-thawing sensitive, complex.

A novel function for the second C2 domain of synaptotagmin. Ca2+-triggered dimerization.

Isoform-specific, calcium-regulated interaction of the synaptic vesicle proteins SV2 and synaptotagmin.

Functional analysis of the C2A domain of synaptotagmin 1: implications for calcium-regulated secretion.

Delineation of the oligomerization, AP-2 binding, and synprint binding region of the C2B domain of synaptotagmin.

Synaptotagmin-1 functions as a Ca2+ sensor for spontaneous release.

UniProtKB entry P21707 (SYT1_RAT)

Manual literature synthesis for rat Syt1