Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Combined Automated Annotation using Multiple IEA Methods

Presenilin is required for activity and nuclear access of Notch in Drosophila.

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation.

The role of presenilin cofactors in the gamma-secretase complex.

In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity.