Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Combined Automated Annotation using Multiple IEA Methods

Nanos interacts with cup in the female germline of Drosophila.

A protein interaction map of Drosophila melanogaster.

Drosophila Cup is an eIF4E-binding protein that functions in Smaug-mediated translational repression.

Cup-ling oskar RNA localization and translational control.

Cup is an eIF4E binding protein required for both the translational repression of oskar and the recruitment of Barentsz.

Drosophila cup is an eIF4E binding protein that associates with Bruno and regulates oskar mRNA translation in oogenesis.

Cup is a nucleocytoplasmic shuttling protein that interacts with the eukaryotic translation initiation factor 4E to modulate Drosophila ovary development.

Efficient protein trafficking requires trailer hitch, a component of a ribonucleoprotein complex localized to the ER in Drosophila.

Bruno acts as a dual repressor of oskar translation, promoting mRNA oligomerization and formation of silencing particles.

Milton controls the early acquisition of mitochondria by Drosophila oocytes.

Staufen- and FMRP-containing neuronal RNPs are structurally and functionally related to somatic P bodies.

nup154 genetically interacts with cup and plays a cell-type-specific function during Drosophila melanogaster egg-chamber development.

Female sterile mutations on the second chromosome of Drosophila melanogaster. II. Mutations blocking oogenesis or altering egg morphology.

Squid, Cup, and PABP55B function together to regulate gurken translation in Drosophila.

The molecular chaperone Hsp90 is a component of the cap-binding complex and interacts with the translational repressor Cup during Drosophila oogenesis.

The spinal muscular atrophy protein SMN affects Drosophila germline nuclear organization through the U body-P body pathway.

Drosophila SMN complex proteins Gemin2, Gemin3, and Gemin5 are components of U bodies.

U bodies respond to nutrient stress in Drosophila.

Drosophila patterning is established by differential association of mRNAs with P bodies.

Human 4E-T represses translation of bound mRNAs and enhances microRNA-mediated silencing.

4E-BPs require non-canonical 4E-binding motifs and a lateral surface of eIF4E to repress translation.

Subcellular localisations of the CPTI collection of YFP-tagged proteins in Drosophila embryos.

The translational regulator Cup controls NMJ presynaptic terminal morphology.

RNA binding proteins Smaug and Cup induce CCR4-NOT-dependent deadenylation of the nanos mRNA in a reconstituted system.

Cup is essential for oskar mRNA translational repression during early Drosophila oogenesis.

The Drosophila gene fs(2)cup interacts with otu to define a cytoplasmic pathway required for the structure and function of germ-line chromosomes.

CUP promotes deadenylation and inhibits decapping of mRNA targets.

Crystal structure of a minimal eIF4E-Cup complex reveals a general mechanism of eIF4E regulation in translational repression.