Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniPathway vocabulary mapping
Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Development of a high-density assay for long-chain fatty acyl-CoA elongases.
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A Unifilter-96 GF/C plate assay was used to profile recombinant human ELOVLs; ELOVL1, -3 and -6 preferentially elongate saturated fatty acyl-CoAs, whereas ELOVL2 and ELOVL5 prefer polyunsaturated acyl-CoAs.
"ELOVL1, -3 and -6 preferably elongated the saturated fatty acyl-CoAs while ELOVL2 and ELOVL5 preferentially elongated the polyunsaturated fatty acyl-CoAs"
ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis.
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The full study assays all seven human ELOVLs, localizes them to ER and reports CERS2 association with each. Individual substrate profiles and functional coupling must be distinguished.
"mammals have seven elongases (ELOVL1-7)"
Two modes of regulation of the fatty acid elongase ELOVL6 by the 3-ketoacyl-CoA reductase KAR in the fatty acid elongation cycle.
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Purified ELOVL6 reconstituted into proteoliposomes catalyzes the rate-limiting condensation step (C16:0-CoA + malonyl-CoA), with KM 1.22 uM for hexadecanoyl-CoA; its activity is stimulated ~3-fold by the 3-ketoacyl-CoA reductase KAR (HSD17B12) both independently of and dependent on KAR catalysis, indicating coordinated function within the elongation machinery.
"The FA elongase ELOVL6 is responsible for the conversion of C16-CoAs to C18-CoAs"
Regulation of mitochondrial morphology and function by stearoylation of TFR1.
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Fly dElovl6 loss reduces C16:0-to-C18:0 elongase activity and C18:0 abundance. Human ELOVL6 expression rescues mutant lethality (Extended Data Fig1D), supporting conserved function; restoration of the C18:0 pool by the human transgene was not separately established in that panel.
"their lethality is rescued by human Elovl6"
Brown Adipose Tissue Thermogenic Capacity Is Regulated by Elovl6.
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Elovl6 converts C16 saturated and monounsaturated fatty acids to C18 and is necessary for brown-adipose-tissue thermogenic capacity in mice; the human ISS/IEA cold-induced-thermogenesis annotations derive from this mouse work.
"Elovl6 acts to convert C16 saturated and monounsaturated fatty acids to C18 fatty acids"
A reference map of the human binary protein interactome.
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Large-scale yeast two-hybrid (HuRI) reference interactome; the ELOVL6 binary hits (HMOX1, LCP2, RTP2) are the basis of the IntAct IPI "protein binding" annotations but carry no ELOVL6-specific functional interpretation.
"A reference map of the human binary protein interactome."
ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA
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ELOVL3, ELOVL6 and ELOVL7 catalyze the ER-membrane condensation of palmitoyl-CoA with malonyl-CoA to form 3-oxooctadecanoyl-CoA, i.e. the rate-limiting C16->C18 condensation step.
"The ER membrane-bound elongation of very long chain fatty acids proteins 3, 6 and 7 (ELOVL3,6,7) catalyse the condensation of palmitoyl-CoA (PALM-CoA) with malonyl-CoA (Mal-CoA) to form 3-oxooctadecanoyl-CoA (3OOD-CoA)"
Synthesis of very long-chain fatty acyl-CoAs
ELOVL6: primary evidence scope checked 2026-09-20
ELOVL6 PAINT lineage, GO definitions and IntAct source checks
Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl-Chain Length and Hepatic Insulin Sensitivity in Mice.