Combined Automated Annotation using Multiple IEA Methods

Huntingtin interacting proteins are genetic modifiers of neurodegeneration.

Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.

PMID:9473517

Characterisation of a new human and murine member of the DnaJ family of proteins.

DNAJC4/HSPF2 was identified as a new member of the DnaJ/HSP40 family; assignment to this family is the basis for its inferred protein-folding/unfolded-protein-response and membrane annotations.

file:human/DNAJC4/DNAJC4-notes.md

Reviewer notes for DNAJC4

Local review notes emphasize that DNAJC4 is a Tdark J-domain protein with family-level HSP70 co-chaperone inference, predicted membrane localization, and no direct experimental characterization of chaperone activity, HSP70 partner, topology, or client repertoire.

file:human/DNAJC4/DNAJC4-pn-notes.md

Proteostasis-network notes for DNAJC4

PN review notes flag that the HSP70 co-chaperone assignment is family-level and unverified experimentally, and that mitochondrial-branch placement is unsupported by the dossier.