Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Cytoplasmic, nuclear, and golgi localization of RGS proteins. Evidence for N-terminal and RGS domain sequences as intracellular targeting motifs.
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RGSZ localizes to the Golgi complex in COS-7 cells due to its N-terminal cysteine-rich region
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Deletion of N-terminal domain promotes nuclear localization
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RGS proteins localize in nucleus, cytoplasm, or shuttle between compartments
Large-scale mapping of human protein-protein interactions by mass spectrometry.
Molecular organization and dynamics of the melatonin MT₁ receptor/RGS20/G(i) protein complex reveal asymmetry of receptor dimers for RGS and G(i) coupling.
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RGS20 directly and constitutively couples to MT1 melatonin receptor
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Forms ternary complex with MT1 receptor and Gi proteins
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Demonstrates receptor specificity for RGS proteins
Next-generation sequencing to generate interactome datasets.
Protein interactions of the transcription factor Hoxa1.
A proteome-scale map of the human interactome network.
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Proteome-scale binary protein-protein interaction map
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Approximately 14,000 high-quality human PPIs identified
An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha.
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RGSZ1 (RGS20) is a GAP with marked preference for Galpha-z
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Expression limited to brain, particularly high in caudate nucleus
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PKC phosphorylation of Galpha-z reduces susceptibility to RGSZ1 action
GPCR downstream signalling
Active G alpha (z) binds RGS proteins
G alpha (i):RGS dissociates to inactive G alpha (i)-i1/i2/i3
G alpha (z):RGS complex dissociates to give inactive G alpha (z)
Active G alpha (i)-i1/i2/i3 binds RGS proteins
G alpha (i)-i1/i2/i3 in G (i):RGS complex is inactivated
G alpha (z) in G alpha (z):RGS complex is inactivated