Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
The myeloid-specific sialic acid-binding receptor, CD33, associates with the protein-tyrosine phosphatases, SHP-1 and SHP-2.
The sialoadhesin CD33 is a myeloid-specific inhibitory receptor.
Engagement of p75/AIRM1 or CD33 inhibits the proliferation of normal or leukemic myeloid cells.
Myeloid specific human CD33 is an inhibitory receptor with differential ITIM function in recruiting the phosphatases SHP-1 and SHP-2.
Constitutive repressor activity of CD33 on human monocytes requires sialic acid recognition and phosphoinositide 3-kinase-mediated intracellular signaling.
ITIM-dependent endocytosis of CD33-related Siglecs: role of intracellular domain, tyrosine phosphorylation, and the tyrosine phosphatases, Shp1 and Shp2.
MicroRNAs enriched in hematopoietic stem cells differentially regulate long-term hematopoietic output.
Epitope mapping, expression and post-translational modifications of two isoforms of CD33 (CD33M and CD33m) on lymphoid and myeloid human cells.
Induction of myelodysplasia by myeloid-derived suppressor cells.
A proteome-scale map of the human interactome network.
FRMD4A-cytohesin signaling modulates the cellular release of tau.
Evidence for C1q-mediated crosslinking of CD33/LAIR-1 inhibitory immunoreceptors and biological control of CD33/LAIR-1 expression.
The Alzheimer's disease-protective CD33 splice variant mediates adaptive loss of function via diversion to an intracellular pool.
Isolation of a cDNA encoding CD33, a differentiation antigen of myeloid progenitor cells.
A reference map of the human binary protein interactome.
A Human IgSF Cell-Surface Interactome Reveals a Complex Network of Protein-Protein Interactions.
Characterization of CD33 as a new member of the sialoadhesin family of cellular interaction molecules.
Exocytosis of tertiary granule membrane proteins
Exocytosis of specific granule membrane proteins
Falcon deep research report for CD33
-
Falcon corroborates the core CD33 model, framing it as a non-enzymatic sialic-acid-recognizing lectin receptor and adding microglial detail that CD33 inhibitory signaling antagonizes the SYK/ERK activation axis.
"In microglia, deletion or functional disruption of CD33 leads to increased phosphorylation of spleen tyrosine kinase (SYK) and extracellular signal-regulated kinases 1 and 2 (ERK1/2), indicating relief from CD33-mediated inhibition"