Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on UniPathway vocabulary mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
UniProt entry A0A1J6KAK0 for Nicotiana attenuata FOX2_4
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FOX2_4 is a BBL-family nicotine-associated oxidoreductase
"Involved in the biosynthesis of pyridine alkaloid natural products, leading mainly to the production of anabasine, anatabine, nicotine and nornicotine ... Catalyzes a late oxidation step subsequent to the pyridine ring condensation reaction in the biosynthesis of alkaloids."
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UniProt places FOX2_4 in vacuole
"CC -!- SUBCELLULAR LOCATION: Vacuole {ECO:0000256|ARBA:ARBA00004116}."
NaBBL FOX2_4 candidate notes
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BBL-family late-pathway chemistry is secure at the family level
"The full preprint shows that a BBL-family enzyme functions as NicGS in the reconstructed nicotine synthase cascade and contributes the pathway's stereochemical control."
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FOX2_4 remains unresolved among the attenuata BBL paralogs
"For FOX2_4, the remaining problem is paralog identification inside the BBL family, not whether BBL biochemistry belongs in the nicotine core pathway."