ift-139 (Q20255, ZK328.7) notes

Provenance and process

• Accession: Q20255 (Swiss-Prot, 1324 aa, TTC21B/IFT139 ortholog); the only UniProt entry for the gene.
• Deep research: just deep-research-falcon worm ift-139 --fallback perplexity-lite failed (falcon timed out at 600 s; the perplexity fallback provider is not available in this environment). No deep-research file was written. The review uses cached publications and PubMed searches instead.

Key findings

• Expressed only in ciliated neurons; IFT-139::GFP sits at the ciliary base and in cilia, with a weak diffuse dendritic signal PMID:27515926.
• Moves on IFT trains PMID:27515926.
• Retrograde role from epistasis PMID:27515926.
• Redundant with IFT-43 for dynein-2 motility PMID:28479320.
• Ciliary gating PMID:30293716.
• Niwa 2016 calls ifta-1 "IFT122"; IFTA-1 is actually IFT121/WDR35 (daf-10 is IFT122).

Curation decisions

• 9 GOA rows: 8 ACCEPT, 1 KEEP_AS_NON_CORE (dendrite IEA).
• 1 NEW row: ciliary basal body (IDA, PMID:27515926). UniProt records this location but GOA does not.
• Core MF is GO:0005198 structural molecule activity, matching the che-11, daf-10 and dyf-2 reviews.

2026-10-09: MF dropped

• Removed GO:0005198 structural molecule activity from the IFT-A core function. It was a generic placeholder with no evidence for a specific structural activity; the IFT-A role is captured by in_complex GO:0030991 and the retrograde transport process.