"mutant APC lacking the S/TXV motif exhibited weaker cell cycle blocking activity than the intact APC"

"the APC basic domain did not contribute to EB1 binding"

"the Axin-APC interaction occurs at a conserved groove"

"APC enhanced the GEF activity of Asef"

"mutation of both APC NESs resulted in the nuclear accumulation of the full-length"

"binding of APC to microtubules increases microtubule stability in vivo and in vitro"

"APC localizes to the ends of microtubules embedded in kinetochores and forms a complex with the checkpoint proteins Bub1 and Bub3"

"Siah-1 interacts with the carboxyl terminus of APC"

"the inhibitory region was localized to the C terminus of APC between residues 2086 and 2394"

"APC and axin colocalize in the nucleus and at lateral cell borders"

"This pathway is Siah2 and APC dependent, but GSK-3 and beta-TrCP independent"

"APC invariably accumulated in the nuclei of Ki-67 expressing cells"

"Crystal structures of phosphorylated and nonphosphorylated APC bound to beta-catenin"

"the crystal structure of beta-catenin in complex with a phosphorylated APC fragment"

"one of these pools represents the fully assembled beta-catenin-targeting complex"

"The thermodynamics of beta-catenin binding to E-cadherin, Lef-1, APC, axin, and the transcriptional inhibitor ICAT have been determined by isothermal titration calorimetry"

"Interaction between hScrib and APC is mediated by the PDZ domains 1 and 4 of hScrib"

"the binding affinities of beta-catenin with an APC 15aa repeat fragment and each of the seven 20aa repeats"

"Asef2 activation involves APC releasing the ABRSH3 from the C-terminal tail"

"loss of APC results in disappearance of cellular protrusions and decreased cell migration"

"inhibition of APC in U2OS cells compromises the mitotic spindle checkpoint"

"the C-terminal segment of the tumor suppressor APC binds much less tightly to PDZ2"

"WTX, a protein encoded by a gene mutated in Wilms tumors, forms a complex with beta-catenin, AXIN1, beta-TrCP2 (beta-transducin repeat-containing protein 2), and APC (adenomatous polyposis coli)"

"Mutations in APC were associated with an increased incidence in cell cycle defects during the completion of cytokinesis"

"the N-terminal region including the Armadillo domain (ARM) of APC is sufficient to bind the Tid molecules"

"both the N-terminal ABR and SH3 domains of Asef2 are responsible for its interaction with APC"

"APC is recruited to the plasma membrane by binding to APC membrane recruitment 1 (AMER1)"

"Exogenously expressed and endogenous APC interacted with EDD in vivo"

"Trabid can bind to and deubiquitylate the APC tumor suppressor protein"

"Striatin is expressed in epithelial cells and co-localizes with APC in the epithelial tight junction compartment"

"Asef2, Neurabin2 and APC were induced to accumulate and colocalize in lamellipodia and membrane ruffles"

"we demonstrate that a short polypeptide motif, Ser-x-Ile-Pro (SxIP), is used by numerous +TIPs, including the tumor suppressor APC, the transmembrane protein STIM1, and the kinesin MCAK, for localization to microtubule tips in an EB1-dependent manner"

"Dishevelled (Dvl) binds to adenomatous polyposis coli (APC) gene product"

"allows the relocalization of APC (adenomatous polyposis coli) and cytoplasmic linker-associated protein 2 (CLASP2), known MT-associated proteins, to the plasma membrane and ruffles"

"Cdc42 interacts directly with the first three armadillo repeats of APC"

"multiple ßcat-binding sites act additively to fine-tune signaling via cytoplasmic retention"

"the crystal structures of the PDZ1 and PDZ2 domains of DLG1 each in complex with the C-terminal 11-residue peptide of APC"

"the complex of APC-Arm with the tyrosine-rich (YY) domain"

"Amer2 recruits APC to the plasma membrane"

"β-catenin is not only phosphorylated inside the Axin1 complex, but also ubiquinated and degraded via the proteasome"

"the crystal structure of the hDlg1 PDZ2-APC complex"

"accessible for phosphorylation by CK1ε in vitro"

"Amer3 binds to the armadillo repeat domain of APC"

"the APC(min) mice could not maintain the core body temperature in cold condition"

"We reprobed a previously published dynein immunoprecipitate from WT mouse brain extracts (Gao et al., 2015) using our APC-M2 antibody and found that full-length APC coprecipitated with dynein (Figure 4B). We also found that dynein coprecipitated with APC (Figure 4C)."

"TMEM9-v-ATPase hyperactivates Wnt/β-catenin signalling via lysosomal degradation of adenomatous polyposis coli (APC)"

"E-cadherin and APC directly compete for binding to the internal, armadillo-like repeats of beta-catenin"

"APC and E-cadherin do not associate with each other either in the presence or absence of catenins"

"identified by sequencing as beta-catenin"

"kinase activity of CDK2 was significantly down-regulated in cells overexpressing APC"

"the carboxyl-terminal region of APC and the DLG homology repeat region of DLG"

"Binding of beta-catenin to this region was dependent on phosphorylation by GSK3 beta"

"Human Axin (hAxin) binds directly to beta-catenin, GSK3 beta, and APC in vitro"

"stimulates complex formation between adenomatous polyposis coli (APC) and beta-catenin"

"APC-B dimerization and recruitment of multiple actin monomers"

"APC plays the central role in assembling the nucleation seed"

"APC promotes β-catenin recruitment, both by direct binding and by facilitating β-catenin binding by AXIN1"

"purified carboxyl-terminal basic domain of human APC protein (APC-basic) bound directly to and bundled actin filaments"

"Silencing APC led to a significant reduction in F-actin density (fluorescence intensity per area) in cells, and these defects were rescued by expression of FL-APC (WT) but not FL-APC (m4)"