CSH1 (P38287, YBR161W) notes

Module: sphingolipid_de_novo_synthesis, MIPC synthase (Csg1/Sur1 paralog). Missing from YeastCyc SPHINGOLIPID-SYN-PWY-1 (only SUR1 listed).

Evidence journal

• Redundancy PMID:12954640
• Distinct specificity PMID:12954640
• Csg2 dependence PMID:12954640
• Vacuole membrane GFP (Huh), heterodimer with Csg2 [UniProt:P38287]

Decisions

• Core MF GO:0103064, BP GO:0051999, complex GO:0031501, Golgi apparatus (IDA). Vacuole rows KEEP_AS_NON_CORE (conflict flagged).
• M(IP)2C metabolic process rows KEEP_AS_NON_CORE (Csh1 makes the MIPC precursor; Ipt1 makes M(IP)2C).
• Generic mannosyltransferase IBA MODIFY to GO:0103064; protein binding (Csg2) REMOVE.