Rrp36 is a conserved nucleolar ribosome-biogenesis factor associated with the 90S preribosome. It supports early processing of the small-subunit rRNA precursor and production of the 40S ribosomal subunit. Comparative experiments in budding yeast and human cells establish a conserved requirement for early pre-rRNA cleavages, while fission yeast localization and curated phylogenetic evidence support the corresponding role of Rrp36. An intrinsic RNA-cleaving activity has not been established.
PomBase primary symbol rrp36, locus SPAC823.04, current UniProt Q9P6P2. The supplied pre-release post-processed-2026_02_28k.xml is the source of the reviewed claims; its placeholder sequence, taxonomy and dates are not biological metadata. The current UniProt sequence is not established as the model input. Current API availability and published-list inclusion are separate properties; all biological judgments here concern the preserved original claims.
Primary reports are interpreted at the species, assay and subunit level. Abstract-only experimental annotations are not rejected because a title foregrounds another subunit. PAINT asserts inheritance from a curated ancestral node; donor count and target self-inclusion are not objections. ARBA overlap is recorded only as provenance, never as biological validation. CNN and LSP reflect established biological knowledge, without asserting training-data membership.
The full original function paragraph and all atomic claims are assessed in rrp36-protnlm-function-review.md.
The Falcon report correctly distinguishes budding yeast/human RRP36 experiments from the fission yeast target; its absence-of-localization finding is incomplete because GOA includes the target tagged-ORFeome observations. The report and primary PMID:20038530 were inspected.