Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000044

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

PMID:16169070

A human protein-protein interaction network: a resource for annotating the proteome.

PMID:16439358

The structure of the mammalian signal recognition particle (SRP) receptor as prototype for the interaction of small GTPases with Longin domains.

The SR is a heterodimeric complex of the two GTPases SRalpha and SRbeta, membrane-anchored; crystal structure of mammalian SRbeta in the Mg2+-GTP-bound state in complex with the SRalpha (SRX) binding domain.

PMID:19664239

Subcellular localization of APMCF1 and its biological significance of expression pattern in normal and malignant human tissues.

EGFP-APMCF1 (SRPRB) overexpressed in COS-7 cells localized generally to the cytoplasm.

PMID:22375059

Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells.

PMID:23264731

MTR120/KIAA1383, a novel microtubule-associated protein, promotes microtubule stability and ensures cytokinesis.

Characterizes MTR120/KIAA1383 as a microtubule-associated protein promoting microtubule stability and cytokinesis.

PMID:33961781

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

PMID:40205054

Multimodal cell maps as a foundation for structural and functional genomics.

Reactome:R-HSA-1791060

Expression of SRPRB (SRP Receptor subunit beta)

PMID:29567807

Structure of a prehandover mammalian ribosomal SRP·SRP receptor targeting complex.

Cryo-EM structure of the mammalian translating ribosome with SRP and SRP receptor in a prehandover conformation; GTP-bound SRbeta and eukaryote-specific SRP/SR proteins form a large assembly at the distal SRP RNA site, and SRP/SR GTP hydrolysis is delayed at this stage to allow signal-sequence handover.

PMID:34020957

Receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.

Structural, biochemical and single-molecule analyses show eukaryotic SRP-mediated targeting requires sequential GTPase-driven compaction of the SRP receptor (SRalpha/SRbeta) and conformational rearrangements that couple the SRP/SR GTPase cycle to protein translocation.

PMID:37643813

Examining SRP pathway function in mRNA localization to the endoplasmic reticulum.

CRISPR/Cas9 knockout of SRPRB (SRbeta) in mammalian cells profoundly destabilizes SRalpha (proteasome-sensitive) and redistributes residual SRalpha to the cytosol, yet steady-state ER mRNA localization is largely unaltered, uncoupling ER mRNA localization from SRP receptor expression.

PMID:36921042

Signal recognition particle receptor-β (SR-β) coordinates cotranslational N-glycosylation.

SRbeta (SRPRB) is required for assembly of an N-glycosylation-competent translocon; perturbing the SRbeta GTP-binding site (mutation or guanine-analog probes) causes hypoglycosylation and reduces SRbeta association with the oligosaccharyltransferase (OST) complex without disrupting SRalpha-SRbeta association, revealing a function coordinating ER translation with N-glycosylation.