NCU08595 is a Rpf2-family ribosome assembly factor with a Brix RNA-binding domain. By conservation with characterized fungal Rpf2, it associates with Rrs1, binds 5S rRNA and promotes incorporation of the 5S ribonucleoprotein particle into nucleolar large-subunit precursors. This assembly step supports large-subunit rRNA maturation.
The exact current accession is Q7SCN3; NCU08595 is retained as the current locus identifier. No independently established formal gene-symbol replacement was found. Original claims are preserved in NCU08595-protnlm-source.json from the live API snapshot retrieved 2026-09-09T03:00:51.831347+00:00. The current sequence is not proven to be the prediction-time input, and placeholder API dates do not establish release or training membership.
The specific domain/family observation used is DR InterPro; IPR039770; Rpf2.. Family membership and characterized relatives establish the inference; ARBA or AI-generated names are not independent functional evidence. PAINT is a curator-reviewed ancestral assertion, not donor-count evidence.
No unresolved GOA assertion remains at the reviewed level of specificity. Experimental observations on relatives are distinguished from target observations.
The actual Falcon report supports a conserved Rpf2-Rrs1 assembly-factor role and correctly distinguishes direct fungal-homolog assays from absent target assays. Its principal additional paper, PMID:26117542, was cached and inspected: the Aspergillus complex structure and biochemical data place it against 5S rRNA, RpL5 and Rsa4. Exact excerpt: "The heterodimer forms
specific contacts with the 5S rRNA, RpL5 and the biogenesis factor Rsa4." This agrees with PMID:25855814 used for the main judgment. Specific residue numbers, essentiality and an autonomous nuclease function are not assigned to NCU08595.