dps1 (O43091, SPBPJ4664.01) review notes

Sources

No deep-research provider output is available for this gene (no provider API keys in
this environment), and no PomBase hand-written description is fetched for S. pombe.
The review rests on the UniProt record and the cached PomBase-cited literature.

Literature

• Cloning and disruption: the dps disruptant has no ubiquinone and no decaprenyl
  diphosphate synthase activity PMID:9133618
  It also shows antioxidant dependence PMID:9133618
• Heterotetramer with Dlp1 PMID:14519123 and both subunits are needed PMID:14519123
• Mitochondrial localisation of Dps1-GFP PMID:24911838
• Cross-species IPI with E. coli IspB PMID:20051244

Audit decisions (2026-11)

• GO:0008299 isoprenoid biosynthetic process: GO:0006744 is not an is_a/part_of
  descendant of GO:0008299 (checked in QuickGO ancestors), so the earlier TOO_GENERAL
  was not valid. Changed all four rows to KEEP_AS_NON_CORE, matching dlp1 and human
  PDSS1/PDSS2.
• GO:0045337 FPP biosynthetic process (PomBase IMP, PMID:9133618): FPP is the
  substrate of the enzyme; MARK_AS_OVER_ANNOTATED (not REMOVE, since the full text is not
  cached), with a suggested question.
• Bare protein binding rows removed under the protein-binding policy.
• Core function agrees with the module annoton (Dps1/PDSS1 catalytic subunit of the
  GO:0097269 heterotetramer).