Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Combined Automated Annotation using Multiple IEA Methods

UniProtKB entry Q9NV66 (TYW1_HUMAN)

TYW1B vs TYW1 conservation of cofactor-binding motifs

Biosynthesis of wybutosine, a hyper-modified nucleoside in eukaryotic phenylalanine tRNA.

Crystal structure of the radical SAM enzyme catalyzing tricyclic modified base formation in tRNA.

4-Demethylwyosine synthase from Pyrococcus abyssi is a radical-S-adenosyl-L-methionine enzyme with an additional [4Fe-4S](+2) cluster that interacts with the pyruvate co-substrate.

Pyruvate is the source of the two carbons that are required for formation of the imidazoline ring of 4-demethylwyosine.

Eukaryotic TYW1 Is a Radical SAM Flavoenzyme.

Insertion of 4-Demethylwyosine in tRNA(Phe) Catalyzed by the Radical S-Adenosyl-l-methionine Enzyme TYW1 Entails Oxidative Cleavage of Pyruvate to Form CO(2).

Wybutosine hypomodification of tRNAphe activates HERVK and impairs neuronal differentiation.

In-depth analysis reveals complex molecular aetiology in a cohort of idiopathic cerebral palsy.

The CIA Targeting Complex Is Highly Regulated and Provides Two Distinct Binding Sites for Client Iron-Sulfur Proteins.

Matching tRNA modifications in humans to their known and predicted enzymes.

Yap5 protein-regulated transcription of the TYW1 gene protects yeast from high iron toxicity.