Gene Ontology annotation through association of InterPro records with GO terms.
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt.
Gene Ontology annotation based on curation of immunofluorescence data
Automatic Gene Ontology annotation based on Rhea mapping.
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods.
The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region.
Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding.
Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2.
Phosphorylation of the PTEN tail regulates protein stability and function.
PTEN expression is reduced in a subset of sporadic thyroid carcinomas: evidence that PTEN-growth suppressing activity in thyroid cancer cells mediated by p27kip1.
Subcellular localization of intracellular protein tyrosine phosphatases in T cells.
Expanding coincident signaling by PTEN through its inositol 1,3,4,5,6-pentakisphosphate 3-phosphatase activity.
Regulation of PTEN phosphorylation and stability by a tumor suppressor candidate protein.
Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases.
PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling.
Pten regulates neuronal arborization and social interaction in mice.
Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines.
Critical role for Daxx in regulating Mdm2.
Ubiquitination regulates PTEN nuclear import and tumor suppression.
NHERF1/EBP50 head-to-tail intramolecular interaction masks association with PDZ domain ligands.
A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis.
A seizure-prone phenotype is associated with altered free-running rhythm in Pten mutant mice.
MAGI-2 Inhibits cell migration and proliferation via PTEN in human hepatocarcinoma cells.
Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities.
PTEN regulation by Akt-EGR1-ARF-PTEN axis.
Haploinsufficiency for Pten and Serotonin transporter cooperatively influences brain size and social behavior.
Rak functions as a tumor suppressor by regulating PTEN protein stability and function.
Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity.
X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization.
PTEN inhibits BMI1 function independently of its phosphatase activity.
Lipid phosphate phosphatase 3 stabilization of beta-catenin induces endothelial cell migration and formation of branching point structures.
Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner.
Pten knockdown in vivo increases excitatory drive onto dentate granule cells.
Upregulated microRNA-29a by hepatitis B virus X protein enhances hepatoma cell migration by targeting PTEN in cell culture model.
Protein interactome reveals converging molecular pathways among autism disorders.
PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma.
A comprehensive functional analysis of PTEN mutations: implications in tumor- and autism-related syndromes.
Insulin-like growth factor (IGF) binding protein 2 functions coordinately with receptor protein tyrosine phosphatase β and the IGF-I receptor to regulate IGF-I-stimulated signaling.
TGFβ-stimulated microRNA-21 utilizes PTEN to orchestrate AKT/mTORC1 signaling for mesangial cell hypertrophy and matrix expansion.
PTEN suppresses the oncogenic function of AIB1 through decreasing its protein stability via mechanism involving Fbw7 alpha.
Phosphorylation of the actin binding protein Drebrin at S647 is regulated by neuronal activity and PTEN.
Breast cancer-derived K172N, D301V mutations abolish Na+/H+ exchanger regulatory factor 1 inhibition of platelet-derived growth factor receptor signaling.
SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer.
Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function.
NHERF1/EBP50 controls morphogenesis of 3D colonic glands by stabilizing PTEN and ezrin-radixin-moesin proteins at the apical membrane.
TIMAP promotes angiogenesis by suppressing PTEN-mediated Akt inhibition in human glomerular endothelial cells.
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
PPARγ Ligands Attenuate Hypoxia-Induced Proliferation in Human Pulmonary Artery Smooth Muscle Cells through Modulation of MicroRNA-21.
Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis.
Electric field-induced suppression of PTEN drives epithelial-to-mesenchymal transition via mTORC1 activation.
The Protective Role of microRNA-200c in Alzheimer's Disease Pathologies Is Induced by Beta Amyloid-Triggered Endoplasmic Reticulum Stress.
The CRL4-DCAF13 ubiquitin E3 ligase supports oocyte meiotic resumption by targeting PTEN degradation.
Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders.
TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta.
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase.
A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast.
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate.
Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN.
The lipid phosphatase activity of PTEN is critical for its tumor supressor function.
Synthesis of PIPs at the plasma membrane
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
PTEN dephosphorylates PIP3
PTEN cancer mutants do not dephosphorylate PIP3
PTEN mRNA translation negatively regulated by microRNAs
USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
Monoubiquitinated PTEN translocates to the nucleus
PTEN undergoes monoubiquitination
USP7 deubiquitinates monoubiquitinated PTEN
Deubiquitinated PTEN translocates to the cytosol
NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
USP13 and OTUD3 deubiquitinate PTEN
Casein kinase II phosphorylates PTEN
PREX2 binds PTEN and inhibits it
A secreted PTEN phosphatase that enters cells to alter signaling and survival.
Proteasome degrades polyubiquitinated PTEN
TRIM27 polyubiquitinates PTEN
OTUD3 deubiquitinates PTEN
PTEN mRNA translation is negatively regulated by microRNAs
MKRN1 polyubiquitinates PTEN
TNKS and TNKS2 PARylate PTEN
RNF146 polyubiquitinates PARylated PTEN
PTEN mRNA translation is inhibited by miR-137
Deep research on PTEN function