Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
ARRDC5 expression is conserved in mammalian testes and required for normal sperm morphogenesis.
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Arrdc5 knockout causes male sterility with defective spermiogenesis.
"Spermiogenesis, the final phase of spermatogenesis when round spermatids transform to spermatozoa, is defective in testes of Arrdc5 deficient mice."
ARRDC5 deficiency impairs spermatogenesis by affecting SUN5 and NDC1.
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ARRDC5 affects SEC22A-mediated trafficking of NDC1 and SUN5.
"We further found that ARRDC5 might affect the vesicle-trafficking protein SEC22A-mediated transport and localization of NDC1, SUN5 and other head-tail coupling apparatus-related proteins that are responsible for initiating the attachment of the sperm head and tail."
Biogenesis and migration of the sperm cytoplasmic droplet require ARRDC5 and TEX38.
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ARRDC5 binds TEX38 and is needed for cytoplasmic droplet biogenesis.
"Here, we demonstrate that two proteins with testis-specific expression, arrestin domain-containing 5 (ARRDC5) and testis expressed 38 (TEX38), physically interact, are required for normal sperm maturation, and play a critical role in CD formation and function."
Disruption of TEX38 impairs sperm morphogenesis and the migration of sperm into the oviduct.
Mammalian α arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with β arrestins.
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ARRDC5 alone among mammalian alpha-arrestins lacks PY motifs.
"With the exception of ARRDC5, all mammalian aArrs have a pair of PY motifs."
Comparative interactome analysis of α-arrestin families in human and Drosophila.
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The ARRDC5 interactome includes V-type ATPase components.
"Additionally, the interactome for an uncharacterized human α-arrestin ARRDC5 uncovered multiple components in the V-type ATPase, which plays a key role in bone resorption by osteoclasts."
UniProt entry A6NEK1 (ARRD5_HUMAN)
Affinage mechanistic annotation for ARRDC5 (human)