Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000052

Gene Ontology annotation based on curation of immunofluorescence data

PMID:18200010

NLRX1 is a regulator of mitochondrial antiviral immunity.

NLRX1 localizes to the mitochondrial outer membrane and interacts with MAVS; it potently inhibits RIG-I-like-helicase- and MAVS-mediated IFN-beta promoter activity and disrupts virus-induced RLH-MAVS interactions, and its depletion enhances virus-induced type I IFN and reduces viral replication.

PMID:21903422

Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.

PMID:27393910

NLRX1 attenuates apoptosis and inflammatory responses in myocardial ischemia by inhibiting MAVS-dependent NLRP3 inflammasome activation.

NLRX1 localizes to mitochondria and inhibits MAVS-dependent NLRP3 inflammasome activation, reducing IL-1beta/IL-18/IL-6, caspase-1 and apoptosis in hypoxia/myocardial-ischemia models.

PMID:28611246

Inhibition of Avian Influenza A Virus Replication in Human Cells by Host Restriction Factor TUFM Is Correlated with Autophagy.

TUFM acts as a host restriction factor against avian influenza in a manner correlated with autophagy; NLRX1 is the IntAct partner for the curated NLRX1-TUFM interaction underlying NLRX1's autophagy-promoting function.

PMID:22749352

The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy.

NLRX1 interacts with the mitochondrial elongation factor TUFM, which recruits the autophagy proteins ATG5-ATG12 (and ATG16L1); the NLRX1-TUFM complex promotes autophagy and dampens type I interferon, linking NLRX1 to autophagy/mitophagy.

PMID:18219313

NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-kappaB and JNK pathways by inducing reactive oxygen species production.

NLRX1 is a mitochondrial NLR that amplifies NF-kappaB and JNK signaling by inducing reactive oxygen species production (i.e. it does not inhibit NF-kappaB in this study).

PMID:34800366

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.

Reactome:R-HSA-936564

NLRX1 inhibits MAVS-DDX58 interaction

Reactome:R-HSA-9749471

NLRX1 binds CHUK:IKBKB:IKBKG

file:human/NLRX1/NLRX1-deep-research-falcon.md

Falcon deep research report for NLRX1

LLM-synthesized review of NLRX1 emphasizing an emerging "unifying" mitophagy-receptor model (direct LC3 binding, acetyl-CoA metabolite sensing), multi-compartment mitochondrial localization (matrix, inner membrane, outer membrane), and negative regulation of RIG-I/MAVS, cGAS-STING and NF-kappaB, while explicitly noting context-/cell-type-dependence of the antiviral effects.