"APS is tyrosine phosphorylated at the C-terminal phosphorylation site conserved among the Lnk family adaptor proteins by stimulation of IL-5 or IL-3 as well as by crosslinking of B cell receptor complex"

"CEACAM1 negatively regulates IL-1β production in LPS activated neutrophils by recruiting SHP-1 to a SYK-TLR4-CEACAM1 complex"

"We demonstrate that SYK phoshorylates Ikaros at unique C-terminal serine phosphorylation sites S358 and S361, thereby augmenting its nuclear localization and sequence-specific DNA binding activity"

"Mechanistically, we establish that SYK-induced Ikaros activation is essential for its nuclear localization and optimal transcription factor function"

"suppression of Syk activation by TULA-2 is mediated, to a substantial degree, by dephosphorylation of Tyr(P)346, a regulatory site of Syk, which becomes phosphorylated soon after receptor ligation and plays a critical role in initiating the process that yields fully activated Syk"

"Tyr 346 and Tyr 342 were strongly phosphorylated in response to GPVI agonists, and this phosphorylation correlated with a profound increase in the phosphorylation of multiple proteins involved in the GPVI-mediated signaling pathway"

"These experiments indicated that phosphorylation of Tyr 519 -Tyr 520 , a marker of Syk activity, is significantly, yet only partially, inhibited by a single mutation of either Tyr 342 or Tyr 346 but is fully blocked by the Y342F/Y346F double mutation"

"we created mice null for the syk gene which showed petechiae in utero and died shortly after birth"

"Irradiated mice reconstituted with Syk-deficient fetal liver showed a block in B-cell development at the pro-B to pre-B cell transition, consistent with a key role for Syk in pre-B-cell receptor signalling"

"whereas the development of alpha beta T cells proceeded normally, Syk-deficient mice showed impaired development of thymocytes using the V gamma 3 variable region gene"

"the tandem SH2 domains of Syk bind dual phosphotyrosine sites in the conserved ITAM motifs of receptor signalling chains, such as the immunoglobulin alpha and beta-chains of the BCR, leading to Syk activation"

"the syk mutation impaired the differentiation of B-lineage cells, apparently by disrupting signalling from the pre-BCR complex and thereby preventing the clonal expansion, and further maturation, of pre-B cells"

"Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells"

"The PLC gamma 1 SH2 domains associate with a prominent 70-72-kDa tyrosine phosphoprotein from anti-mu-stimulated, but not resting, B cells...definitively identify this protein as p72syk"

"our ability to co-immunoprecipitate p72syk and PLC gamma 1 from lysates of anti-mu-stimulated B cells. These results implicate p72syk in the activation of phospholipase C gamma 1 during B cell antigen receptor signaling"

"Syk expression reconstituted several signaling events upon anti-IgM stimulation, including Syk phosphorylation and association with the BCR, tyrosine phosphorylation of numerous proteins including Shc, and activation of mitogen-activated protein kinase"

"A catalytically inactive Syk mutant could associate with the BCR and become tyrosine phosphorylated but could not reconstitute downstream signaling events"

"This interaction of BTK with SRC kinases transphosphorylated BTK on tyrosine at residue 551, which led to BTK activation"

"Disruption of epithelial gamma delta T cell repertoires by mutation of the Syk tyrosine kinase"

"the ability of Syk and SykB to undergo autophosphorylation and to phosphorylate erythrocyte band 3 in immune complex kinase reactions was at least 100-fold greater than that of Zap-70"

"the intrinsic enzymatic activity of Syk and SykB is superior to that of Zap-70 and that such a distinction relates to structural variations in the catalytic domain"

"Using Syk-deficient mast cells we show that they fail to degranulate, synthesize leukotrienes and secrete cytokines when stimulated through Fc epsilon RI, conclusively demonstrating an essential role for Syk in Fc epsilon RI signalling"

"our data strongly supports a model of Fc epsilon RI engagement leading to the sequential activation of the tyrosine kinases Lyn and then Syk"

"Syk activation and dissociation from the B-cell antigen receptor is mediated by phosphorylation of tyrosine 130"

"Shc contains two Grb2 binding sites needed for efficient formation of complexes with SOS in B lymphocytes"

"in mice lacking both Syk and ZAP-70, DN thymocytes undergo beta chain gene rearrangement but fail to initiate clonal expansion and are incapable of differentiating into DP cells after expression of the pre-TCR"

"in αβ lineage T cells, Syk and ZAP-70 act jointly in the differentiation of DN to DP cells, most probably due to a role in signaling by the pre-TCR"

"Macrophages derived from Syk-deficient (Syk-) mice were defective in phagocytosis of particles bound by FcgammaRs"

"We found that FcγR-mediated Syk activation was impaired in Hck−/Fgr−/Lyn− macrophages. This observation provides additional strong evidence for a model of sequential activation of Src family and Syk tyrosine kinases by the FcγRs."

"Alternatively, the physical association of Syk with phosphorylated receptor tails may allow it to serve an adaptor-type function at cross-linked receptors to allow recruitment of other important proteins to the site of particle binding."