G6PC2 (human): Bgee expression evidence

Generated by projects/BGEEDB_EXPRESSION/scripts/gene_report.py; do not edit. Source: Bgee 15.2 (human simple call files for present/absent calls with stages merged; REST API for stage-resolved present calls). Method and tier definitions: projects/BGEEDB_EXPRESSION/methods.md.

Command:

uv run python projects/BGEEDB_EXPRESSION/scripts/gene_report.py human G6PC2 --paralog G6PC1 --paralog G6PC3 --context gluconeogenesis:UBERON:0002107,UBERON:0001225,UBERON:0002108 --focus UBERON:0000006 --focus UBERON:0001264 --focus UBERON:0002107 --focus UBERON:0002113

1. Where the gene and its paralogs are expressed

gene	Bgee id	present / sampled entities	breadth	top present tissues (score)
G6PC2	ENSG00000152254	67 / 100	0.67	islet of Langerhans (99); pancreas (88); body of pancreas (84); duodenum (51); left testis (47); testis (47); right testis (45); metanephros cortex (43)
G6PC1	ENSG00000131482	66 / 244	0.27	right lobe of liver (98); liver (97); nephron tubule (92); buccal mucosa cell (90); jejunal mucosa (90); kidney epithelium (90); renal glomerulus (87); metanephric glomerulus (87)
G6PC3	ENSG00000141349	278 / 287	0.97	adenohypophysis (98); pituitary gland (97); right adrenal gland (97); right adrenal gland cortex (97); left adrenal gland (97); left adrenal gland cortex (97); C1 segment of cervical spinal cord (97); adrenal cortex (96)

2. GO terms with a GO anatomy, scored for the gene and each paralog

Tier per gene: ENRICHED (present in the term's anatomy and in the gene's own top 10%), CONSISTENT, ABSENT (calls exist there, all absent), ABSENT_DEVELOPMENTAL (absent, but the term is developmental and calls merge stages), NO_DATA. A paralog that is detected where the gene is absent shows the anatomy was sampled.

GO term	anatomy	G6PC2	G6PC1	G6PC3
none of the gene's GO terms names an anatomy

3. Context checks for terms without GO anatomy

context	gene	present in context	best in context	top-10 in context (chance)	breadth
gluconeogenesis (liver, cortex of kidney, small intestine)	G6PC2	8 present, 0 absent	UBERON:0002114 duodenum (50.5)	2/10 (0.9)	0.67
gluconeogenesis (liver, cortex of kidney, small intestine)	G6PC1	14 present, 0 absent	UBERON:0001114 right lobe of liver (98.0)	5/10 (1.8)	0.27
gluconeogenesis (liver, cortex of kidney, small intestine)	G6PC3	14 present, 0 absent	UBERON:0010533 metanephros cortex (96.4)	1/10 (0.4)	0.97

Calls inside the gluconeogenesis context, by gene (gold/silver; state, score):

G6PC2: duodenum present (51); metanephros cortex present (43); liver present (41); right lobe of liver present (40); cortex of kidney present (38); small intestine present (33)
G6PC1: right lobe of liver present (98); liver present (97); jejunal mucosa present (90); renal glomerulus present (87); metanephric glomerulus present (87); duodenum present (76); cortex of kidney present (74); ileal mucosa present (73); jejunum present (70); small intestine present (69); small intestine Peyer's patch present (68); metanephros cortex present (50)
G6PC3: metanephros cortex present (96); cortex of kidney present (93); small intestine Peyer's patch present (92); small intestine present (92); renal glomerulus present (90); metanephric glomerulus present (90); duodenum present (89); right lobe of liver present (88); jejunal mucosa present (85); jejunum present (85); ileal mucosa present (83); liver present (82)

4. Stage-resolved present calls in anatomies of interest

Present calls only (the API reports no absent calls); a missing stage means no call, not absence. Stages broader than one developmental window (life cycle, organogenesis stage) are omitted.

UBERON:0000006 islet of Langerhans and its parts

gene	entity	stage	start (dpc)	score	data types
—	no stage-resolved present call

Stage-merged calls (present and absent) in islet of Langerhans and its parts:

G6PC2: islet of Langerhans present (gold, 99)
G6PC1: type B pancreatic cell absent (gold, 49); islet of Langerhans present (gold, 69)
G6PC3: islet of Langerhans present (gold, 93); type B pancreatic cell present (silver, 92)

UBERON:0001264 pancreas and its parts

gene	entity	stage	start (dpc)	score	data types
G6PC3	pancreatic ductal cell	life cycle	0.5	90.7	Affymetrix

Stage-merged calls (present and absent) in pancreas and its parts:

G6PC2: islet of Langerhans present (gold, 99); pancreas present (gold, 88); body of pancreas present (gold, 84)
G6PC1: epithelial cell of pancreas absent (gold, 52); pancreatic ductal cell absent (silver, 49); type B pancreatic cell absent (gold, 49); islet of Langerhans present (gold, 69); pancreas present (gold, 53); body of pancreas present (gold, 44)
G6PC3: body of pancreas present (gold, 94); islet of Langerhans present (gold, 93); pancreas present (gold, 92); type B pancreatic cell present (silver, 92); pancreatic ductal cell present (silver, 91); epithelial cell of pancreas present (silver, 73)

UBERON:0002107 liver and its parts

gene	entity	stage	start (dpc)	score	data types
G6PC1	liver	infant stage	23.5	96.9	RNA-Seq
G6PC1	liver	juvenile stage	42.5	98.1	Affymetrix
G6PC2	liver	life cycle	0.5	40.9	EST
G6PC3	liver	infant stage	23.5	84.2	RNA-Seq

Stage-merged calls (present and absent) in liver and its parts:

G6PC2: liver present (silver, 41); right lobe of liver present (gold, 40)
G6PC1: right lobe of liver present (gold, 98); liver present (gold, 97)
G6PC3: right lobe of liver present (gold, 88); liver present (gold, 82)

UBERON:0002113 kidney and its parts

gene	entity	stage	start (dpc)	score	data types
G6PC3	renal glomerulus	life cycle	0.5	90.1	Affymetrix
G6PC3	nephron tubule	life cycle	0.5	90.7	Affymetrix

Stage-merged calls (present and absent) in kidney and its parts:

G6PC2: metanephros cortex present (gold, 43); cortex of kidney present (gold, 38); kidney present (gold, 35); adult mammalian kidney present (gold, 31)
G6PC1: nephron tubule present (gold, 92); kidney epithelium present (gold, 90); renal glomerulus present (silver, 87); metanephric glomerulus present (silver, 87); adult mammalian kidney present (gold, 83); kidney present (gold, 81); cortex of kidney present (gold, 74); renal medulla present (gold, 72); metanephros present (gold, 69); metanephros cortex present (gold, 50)
G6PC3: metanephros cortex present (gold, 96); adult mammalian kidney present (gold, 94); cortex of kidney present (gold, 93); metanephros present (gold, 92); kidney present (gold, 92); renal medulla present (gold, 91); nephron tubule present (gold, 91); renal glomerulus present (gold, 90); kidney epithelium present (gold, 90); metanephric glomerulus present (gold, 90)