Gene Ontology annotation reference GO_REF:0000033
Gene Ontology annotation reference GO_REF:0000044
The Raine syndrome protein FAM20C is a Golgi kinase that phosphorylates bio-mineralization proteins.
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CG3631 is the fly FAM20 protein most closely related to FAM20B; CG31145 is the FAM20C-like paralog.
"CG3631, which is most closely related to FAM20B"
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V5-tagged CG3631 is retained in S2 cells and overlaps ER and Golgi markers.
"CG3631 overlapped both ER and Golgi markers, and was not detectably secreted from S2 cells"
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The casein kinase activity reported for a fly FAM20 protein is for CG31145, not CG3631.
"Drosophila CG31145 also has Casein kinase activity (not shown)."
Structure and evolution of the Fam20 kinases.
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Drosophila has one Fam20B and one Fam20C; linker xylose phosphorylation occurs in Drosophila and is probably due to Fam20B.
"fruit fly ( Drosophila melanogaster ) has one copy each of Fam20B and Fam20C"
FAM20B is a kinase that phosphorylates xylose in the glycosaminoglycan-protein linkage region.
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Human FAM20B phosphorylates the linkage-region xylose and regulates the number of glycosaminoglycan chains.
"we identified FAM20B as a kinase that phosphorylates the xylose residue in the linkage region"
UniProtKB/Swiss-Prot entry Q95T10 (XYLK_DROME)