Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans.
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Duplication containing sir-2.1 confers lifespan extension up to 50%
"a duplication containing sir-2.1-the C. elegans gene most homologous to yeast SIR2-confers a lifespan that is extended by up to 50%"
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sir-2.1 functions upstream of daf-16 in insulin-like signaling pathway
"the sir-2.1 transgene functions upstream of daf-16 in the insulin-like signalling pathway"
Sirtuin activators mimic caloric restriction and delay ageing in metazoans.
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Resveratrol and STACs activate sirtuins and extend lifespan
"resveratrol and other STACs activate sirtuins from Caenorhabditis elegans and Drosophila melanogaster, and extend the lifespan of these animals"
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Lifespan extension is dependent on functional Sir2
"Lifespan extension is dependent on functional Sir2"
Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO.
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sir-2.1 null mutants show slight decrease in lifespan and stress sensitivity
"sir-2.1(ok434) mutants show a slight decrease in life span as well as sensitivity to various stresses"
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sir-2.1 required for lifespan extension by caloric restriction
"sir-2.1 is required for life span extension by caloric restriction"
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sir-2.1 and daf-16 have overlapping and distinct roles
"sir-2.1 and daf-16 have overlapping and distinct roles in life span regulation"
C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span.
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14-3-3 proteins FTT-2 and PAR-5 are SIR-2.1 binding partners
"We identify two C. elegans 14-3-3 proteins as SIR-2.1 binding partners"
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14-3-3 required for SIR-2.1-mediated lifespan extension
"14-3-3 genes are required for the life-span extension conferred by extra copies of sir-2.1"
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SIR-2.1 binds DAF-16 following heat stress in 14-3-3-dependent manner
"Following heat stress, SIR-2.1 can bind DAF-16 in a 14-3-3-dependent manner"
C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO.
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14-3-3 proteins physically interact with SIR-2.1 and DAF-16
"We identify two C. elegans 14-3-3 proteins as interacting proteins of a major life span regulator"
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Overexpression of 14-3-3 extends lifespan in DAF-16-dependent manner
"overexpression of either 14-3-3 protein (PAR-5 or FTT-2) extends life span and that this is dependent on DAF-16"
C. elegans SIR-2.1 translocation is linked to a proapoptotic pathway parallel to cep-1/p53 during DNA damage-induced apoptosis.
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sir-2.1 essential for apoptosis in response to DNA damage
"sir-2.1 is essential for the execution of apoptosis in response to DNA damage"
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sir-2.1 acts parallel to cep-1/p53
"sir-2.1 genetically acts in parallel to the worm p53-like gene cep-1"
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SIR-2.1 translocates from nucleus to cytoplasm during apoptosis
"During apoptosis SIR-2.1 changes its subcellular localization from the nucleus to the cytoplasm"
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SIR-2.1 colocalizes with CED-4 at nuclear periphery
"transiently colocalizes with the C. elegans Apaf-1 homolog CED-4 at the nuclear periphery"
HIS-24 linker histone and SIR-2.1 deacetylase induce H3K27me3 in the Caenorhabditis elegans germ line.
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SIR-2.1 and HIS-24 essential for H3K27me3 in germline
"SIR-2.1 and HIS-24 that are together essential for maintenance of the H3K27me3 mark in the germ line"
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SIR-2.1 deacetylates H3K9 at subtelomeric regions
"We report that SIR-2.1 deacetylates H3K9 at subtelomeric regions"
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SIR-2.1 and HIS-24 associate with subtelomeric regions
"SIR-2.1 and HIS-24 associate with the subtelomeric regions"
Caenorhabditis elegans dosage compensation regulates histone H4 chromatin state on X chromosomes.
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SIR-2.1 required for reduction of H4K16ac on dosage-compensated X chromosomes
"Depletion of H4K16ac also requires the conserved histone deacetylase SIR-2.1"
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H4K16 acetylation is underrepresented on hermaphrodite X chromosomes
"H4K16 acetylation (H4K16ac) is underrepresented and H4K20 monomethylation (H4K20me1) is enriched on hermaphrodite X chromosomes"
Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated biotin-dependent carboxylases.
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This paper focuses on SIR-2.2 and SIR-2.3, the SIRT4 orthologs
"the Caenorhabditis elegans SIR-2.2 and SIR-2.3 orthologs of SIRT4"
The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling.
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NAD+ restoration prevents age-associated decline and promotes longevity
"Conversely, genetic or pharmacological restoration of NAD(+) prevents age-associated metabolic decline and promotes longevity in worms"
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Effects dependent on sir-2.1
"These effects are dependent upon the protein deacetylase sir-2.1"
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Involves activation of mitochondrial UPR and DAF-16/FOXO
"involve the induction of mitonuclear protein imbalance as well as activation of stress signaling via the mitochondrial unfolded protein response"
Deep research report on sir-2.1