file:MEDTR/DMI1/DMI1-record-evidence.yaml

Compact archived record and sequence evidence for Q6RHR6

Gene Ontology annotation through association of InterPro records with GO terms

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

PMID:27230377

Nuclear-localized cyclic nucleotide-gated channels mediate symbiotic calcium oscillations.

CNGC15a/b/c are nuclear-envelope Ca2+-permeable channels that form a complex with the potassium-permeable channel DMI1.

"We demonstrate that the cyclic nucleotide-gated channels form a complex with the postassium-permeable channel, which modulates nuclear Ca(2+) release."

PMID:14963334

Medicago truncatula DMI1 required for bacterial and fungal symbioses in legumes.

Cloning of DMI1, required for both rhizobial and mycorrhizal symbioses; encodes a protein similar to an archaeal ligand-gated cation channel.

PMID:17173544

The symbiotic ion channel homolog DMI1 is localized in the nuclear membrane of Medicago truncatula roots.

Functional DMI1-GFP localizes to the nuclear envelope.

PMID:17631529

The Medicago truncatula DMI1 protein modulates cytosolic calcium signaling.

DMI1 C-terminal RCK region is regulatory; DMI1 modulates Ca2+ release in yeast and is proposed to regulate Ca2+ channels rather than release Ca2+ itself.

"This work suggests that DMI1 is not directly responsible for Nod factor-induced calcium changes, but does have the capacity to regulate calcium channels in both yeast and plants."

PMID:21825141

Nuclear membranes control symbiotic calcium signaling of legumes.

DMI1 is preferentially located in the inner nuclear membrane.

PMID:22706284

The recent evolution of a symbiotic ion channel in the legume family altered ion conductance and improved functionality in calcium signaling.

A selectivity-filter Ser-to-Ala substitution made DMI1 solo sufficient for symbiosis, replacing both Lotus CASTOR and POLLUX; bilayer recordings of DMI1.

PMID:31420535

Ca(2+)-regulated Ca(2+) channels with an RCK gating ring control plant symbiotic associations.

Lotus CASTOR (a DMI1 homolog) behaves as a Ca2+-regulated Ca2+ channel, challenging the K+ counter-ion model; homolog evidence only.

PMID:35972963

Constitutive activation of a nuclear-localized calcium channel complex in Medicago truncatula.

Gain-of-function DMI1 RCK-interface mutations (S760N) cause spontaneous Ca2+ oscillations and nodulation in a CNGC15-dependent manner.

PMID:39140702

CNGC15 and DMI1 ion channel gating in nuclear calcium signaling: opening new questions and closing controversies.

Review of DMI1 and CNGC15 gating; exact function of DMI1 remains open.

PMID:39814887

Autoactive CNGC15 enhances root endosymbiosis in legume and wheat.

DMI1 is required to activate CNGC15 and acts as pacemaker of nuclear Ca2+ oscillation frequency; a K+-selective DMI1 pore variant is fully functional.

file:MEDTR/DMI1/DMI1-deep-research-falcon.md

Deep research report on Medicago truncatula DMI1 (falcon)