PSCA (human, O43653) curation notes

Deep research providers were unavailable in this environment (just deep-research-falcon human PSCA --fallback perplexity-lite failed: provider not configured). Findings below come from the cached
publications and the UniProt record.

Localization

• GPI-anchored cell-surface protein: PMID:9465086; UniProt
  SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9465086}; Lipid-anchor, GPI-anchor.
  Signal peptide 1-11, chain 12-83, GPI propeptide 84-114, five disulfides (LU/three-finger fold).
• Soluble pools: GPLD1 can cleave GPI anchors [Reactome:R-HSA-8940388]; PSCA is found in prostatic
  exosomes PMID:23533145.
• Benchmark conclusion: cell surface, fully extracellular, GPI-anchored.

Function

• Lynx/Ly-6 family nAChR modulator: PMID:25680266; present in human cortex and increased ~70% in Alzheimer medial frontal gyrus.
• UniProt also notes a cell-proliferation inhibition activity in vitro (PubMed:18488030), not
  currently annotated in GOA; not proposed as NEW because the mechanism and the entity performing
  the step are undefined.

Review decisions

• All four localization rows (IBA, IDA, IEA SubCell, TAS) accepted as plasma membrane; the Reactome
  extracellular-region row kept as non-core (shed form), likewise exosome and the inter-ontology
  synapse inference.
• Both nAChR activity/binding rows and the three signalling-process rows accepted; these form the
  single core function.