psd1 (SPBC16E9.18, UniProt O14333) notes
- Mitochondrial PSD1/PISD-family enzyme (PTHR10067:SF6), pyruvoyl proenzyme [UniProt:O14333].
- psd1/psd2 are Psd1-like, psd3 Psd2-like PMID:19286980.
- Triple deletion needed for phenotype: "psd1-3Delta cells produce lower levels of phosphatidylethanolamine than wild-type cells, even in medium supplemented with ethanolamine" PMID:19286980. No single-enzyme activity assay exists; MF from IMP/IGI.
- Localization: "SpPsd1-mNG localized to mitochondria" and "we did not detect obvious ER targeting of SpPsd1" PMID:34818062; "SpPsd1 is required for respiratory growth, while SpPsd2 was dispensable" PMID:34818062.
- Difference from S. cerevisiae PSD1 review: the S. cerevisiae review has a second core function (ER-localized Psd1 pool, lipid droplets); in S. pombe no ER pool of psd1 is detected, and the LD role is carried by psd2 instead PMID:34818062.
- Module note: psd2 (Q9UTB5) localizes to mitochondria, ER and LDs PMID:34818062, which resolves the module's open question about psd2 compartment (GO-CAM says ER membrane; UniProt says mitochondrial).