Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

Human methionine synthase reductase, a soluble P-450 reductase-like dual flavoprotein, is sufficient for NADPH-dependent methionine synthase activation.

Human methionine synthase reductase is a molecular chaperone for human methionine synthase.

Crystal structure and solution characterization of the activation domain of human methionine synthase.

Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase.

Mechanism of coenzyme binding to human methionine synthase reductase revealed through the crystal structure of the FNR-like module and isothermal titration calorimetry.

Restricted role for methionine synthase reductase defined by subcellular localization.

Interaction between MMACHC and MMADHC, two human proteins participating in intracellular vitamin B₁₂ metabolism.

Methionine synthase and methionine synthase reductase interact with MMACHC and with MMADHC.

Cloning and mapping of a cDNA for methionine synthase reductase, a flavoprotein defective in patients with homocystinuria.

MTR transfers CH3 from MeCbl to HCYS

MTRR reduces cob(II)alamin to meCbl

MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin

cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR

Defective MTRR does not convert cob(II)alamin to MeCbl

Defective MTR does not transfer CH3 group from MTHF to cob(I)alamin

Defective MTR does not transfer CH3 group from MeCbl to HCYS

Cobalamin (Cbl) metabolism