The selected Q8IMZ2 sequence has 559 residues. Exact comparison with long Orb Q9VCN7 establishes an identical 552-residue C-terminal region containing the RNA-binding machinery. This supports broad functional transfer, while not proving identical N-terminal regulation. PMID:27791065(https://pubmed.ncbi.nlm.nih.gov/27791065/) directly compares Orb and Orb2 RNA-binding preferences; only Orb findings are transferred. PMID:15737929(https://pubmed.ncbi.nlm.nih.gov/15737929/) establishes Orb-dependent translation and localization. PMID:11809824(https://pubmed.ncbi.nlm.nih.gov/11809824/) full text directly assays Orb expression and mutant cysts despite its MEI-218 title. The 13 GOA rows are reviewed; broad binding annotations are specified, while developmental consequences remain noncore.
The selected frozen UniProt record is retained in orb-uniprot-source.json, with the complete original prediction metadata in orb-predictions-source.json. It maps the exact accession to this FlyBase gene; current sequence identity does not establish the historical predictor input. Gene-level experiments support conserved functions unless a relevant isoform difference is established. Falcon research was requested with perplexity-lite fallback alongside publication caching. Primary publications and sequence observations, rather than AI summaries or ARBA assertions, support the curated conclusions.
The wrapper timed out and its fallback reported insufficient quota, but the original Falcon job later produced a complete report. The report and primary sources were inspected; no duplicate provider submission was made. The report supports Orb-specific CPEB RNA binding and translational regulation, distinguishing Orb2. It does not establish differences among Q8IMZ2 isoforms; local sequence comparison supports retention of the RNA-binding machinery.