Gene Ontology annotation through association of InterPro records with GO terms.
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt.
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara.
Expression of uteroglobin in the human endometrium.
Interaction of uteroglobin with lipocalin-1 receptor suppresses cancer cell motility and invasion.
Uteroglobin interacts with the heparin-binding site of fibronectin and prevents fibronectin-IgA complex formation found in IgA-nephropathy.
Next-generation sequencing to generate interactome datasets.
Innate immunity proteins and a new truncated form of SPLUNC1 in nasopharyngeal aspirates from infants with respiratory syncytial virus infection.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
A proteome-scale map of the human interactome network.
Architecture of the human interactome defines protein communities and disease networks.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Deep research analysis for SCGB1A1
Falcon (Edison) deep research analysis for SCGB1A1
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SCGB1A1 encodes a small secreted homodimeric secretoglobin
(uteroglobin/CC10/CC16/CCSP) whose function is best supported as an
extracellular immunomodulator at the airway barrier rather than as a
metabolic enzyme.
"SCGB1A1 encodes a highly abundant, secreted airway protein (often referred to as CCSP/CC16/CC10) produced constitutively primarily by airway club cells (non-ciliated secretory epithelial cells), with protein readily detectable in airway lining fluid and also measurable in blood and urine
"
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The protein is a secretoglobin homodimer with an antiparallel
dimerization architecture and a central hydrophobic cavity that binds
phospholipids, steroids and inflammatory mediators.
"structure is described as antiparallel dimerization with a central hydrophobic cavity that can bind hydrophobic ligands (e.g., phospholipids, steroids, inflammatory mediators)
"
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SCGB1A1/CC10 antagonizes phospholipase A2 activity, with increased
PLA2 activity observed in CCSP-deficient contexts.
"Multiple sources describe SCGB1A1/CC10 as a phospholipase A2-inhibitory protein and note increased PLA2 activity in CCSP-deficient contexts
"
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Recombinant CCSP/SCGB1A1 binds CXCL8/IL-8 and inhibits neutrophil
chemotaxis; CCSP deficiency increases airway neutrophilia after injury.
"Recombinant human CCSP/SCGB1A1 can bind CXCL8/IL-8 and inhibit neutrophil chemotaxis, and CCSP deficiency in animal models is associated with greater airway neutrophilia after injurious stimuli
"
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CCSP is described as antagonizing neutrophil adhesion through
interaction with VLA-4 (alpha4beta1 integrin).
"CCSP is described as potentially antagonizing neutrophil adhesion through interaction with VLA-4 (α4β1 integrin)
"
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A 2024 mechanistic study reports CC10/SCGB1A1 suppresses Th2-type
allergic airway inflammation by modulating lung dendritic cell subsets
and activation through an NF-kappaB-linked pathway, rather than acting
directly on T helper cells.
"CC10/SCGB1A1 suppresses Th2-type inflammation largely by modulating lung DC subsets and activation through an NF-κB–linked pathway
"
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SCGB1A1 expression is cytokine-regulated; Th2 cytokines can
downregulate SCGB1A1 while Th1-related pathways regulate expression via
JAK-STAT/FOXA factors.
"Th2 cytokines can downregulate SCGB1A1 and Th1-related pathways can regulate expression via JAK–STAT/FOXA factors
"
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The protein is secreted into airway lumen/lining fluid with measurable
spillover into blood and urine, and is detectable across serum/plasma,
sputum, BALF, nasal secretions and urine.
"detectable in serum/plasma, sputum, bronchoalveolar lavage fluid (BALF), nasal secretions, and urine, consistent with secretion into airway lumen and translocation into the circulation
"
UniProt record for SCGB1A1
Regulation of Clara cell 10 kD protein secretion by pilocarpine: quantitative comparison of nonciliated cells in rat bronchi and bronchioles based on laser scanning confocal microscopy.
Regulation of TH2 responses by the pulmonary Clara cell secretory 10-kd protein.