Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Gene Ontology annotation of human sequence-specific DNA binding transcription factors (DbTFs) based on the TFClass database
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
The N-terminal transactivation domain of ATF2 is a target for the co-operative activation of the c-jun promoter by p300 and 12S E1A.
-
The cached abstract for this publication focuses on ATF2, p300/CBP, E1A, and the c-jun promoter and does not mention ATF3; the full text was not available locally to verify the IntAct ATF3-JUN interaction record.
"The N-terminal transactivation domain of ATF2 is a target for the co-operative activation of the c-jun promoter by p300 and 12S E1A."
An alternatively spliced isoform of transcriptional repressor ATF3 and its induction by stress stimuli.
-
Stress-induced ATF3DeltaZip2 localizes to nuclei, lacks ATF/CRE binding, and counteracts full-length ATF3 repression.
"ATF3DeltaZip2 protein was shown to be localized in the nuclei and counteracted the transcriptional repression by the full-length ATF3."
Interactions among LRF-1, JunB, c-Jun, and c-Fos define a regulatory program in the G1 phase of liver regeneration.
-
LRF-1/ATF3 with Jun proteins can activate CRE-containing promoters, while LRF-1/JunB can repress c-Fos/c-Jun-mediated activation.
"LRF-1 in combination with either Jun protein strongly activates a cyclic AMP response element-containing promoter which c-Fos/Jun does not activate."
Roles of CHOP/GADD153 in endoplasmic reticulum stress.
-
This CHOP/GADD153 ER-stress review does not directly support an ATF3 annotation.
"we summarize the current understanding of the roles of CHOP/GADD153 in ER stress-mediated apoptosis and in diseases including diabetes, brain ischemia and neurodegenerative disease"
ATF5 increases cisplatin-induced apoptosis through up-regulation of cyclin D3 transcription in HeLa cells.
-
This publication is about ATF5, not ATF3; ATF3 annotations citing it should be removed.
"ATF5 transcription factor plays an essential role in hematopoietic and glioma cell survival and neuronal cell differentiation"
A protein-protein interaction network of transcription factors acting during liver cell proliferation.
Fibronectin type I repeat is a nonactivating ligand for EphA1 and inhibits ATF3-dependent angiogenesis.
ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells.
Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays.
An atlas of combinatorial transcriptional regulation in mouse and man.
Networks of bZIP protein-protein interactions diversified over a billion years of evolution.
Role of activating transcription factor 3 (ATF3) in endoplasmic reticulum (ER) stress-induced sensitization of p53-deficient human colon cancer cells to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis through up-regulation of death receptor 5 (DR5) by zerumbone and celecoxib.
-
ATF3 mediates ER stress-induced DR5 expression and sensitization to TRAIL-mediated apoptosis in p53-deficient colorectal cancer cells.
"we demonstrate that the stress response gene ATF3 is required for endoplasmic reticulum stress-mediated DR5 induction upon zerumbone (ZER) and celecoxib (CCB) in human p53-deficient colorectal cancer cells"
Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers.
-
ATF-family bZIP proteins bind ATF sites and form selective DNA-binding heterodimers.
"some, but not all, combinations of ATF proteins form heterodimers that efficiently bind to DNA"
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
Combinatorial bZIP dimers display complex DNA-binding specificity landscapes.
-
ATF3 DNA-binding specificity is strongly partner-dependent and best explained by multiple ATF3-containing bZIP dimers.
"Genome-wide binding of ATF3 is best explained by considering many dimers in which it participates."
Impact of cytosine methylation on DNA binding specificities of human transcription factors.
Architecture of the human interactome defines protein communities and disease networks.
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells.
A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.
Maximizing binary interactome mapping with a minimal number of assays.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
A functionally defined high-density NRF2 interactome reveals new conditional regulators of ARE transactivation.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
AI-guided pipeline for protein-protein interaction drug discovery identifies a SARS-CoV-2 inhibitor.
Mapping adipocyte interactome networks by HaloTag-enrichment-mass spectrometry.
ATF3 and ATF3 delta Zip. Transcriptional repression versus activation by alternatively spliced isoforms.
-
Full-length ATF3 represses ATF-site promoters, while ATF3 delta Zip lacks DNA binding and can stimulate transcription by relieving repression.
"ATF3 represses rather than activates transcription from promoters with ATF sites"
Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10.
-
ATF3 is stress induced, binds ATF/CRE DNA as a homodimer, represses transcription, and forms a nonfunctional heterodimer with CHOP/GADD153.
"ATF3-interacting protein gadd153/Chop10 forms a nonfunctional heterodimer with ATF3; the heterodimer, in contrast to the ATF3 homodimer, does not bind to the ATF/cyclic AMP response element consensus site and does not repress transcription."
ATF4, CEBPB, and ATF3 bind the CHAC1 promoter
ATF3 binding to CD274 gene
Falcon deep research report for human ATF3
-
ATF3 is a stress-inducible nuclear bZIP transcription factor whose core role is partner-dependent transcriptional regulation.
"Human ATF3 is best annotated as a stress-inducible nuclear bZIP transcription factor that binds CRE-like motifs and acts via partner-dependent dimerization to remodel transcriptional programs across stress, immunity, metabolism, and cell fate."
-
Recent work places ATF3 downstream of ISR/eIF2alpha-ATF4 signaling in several stress-response contexts.
"Human ATF3 is best annotated as a stress-inducible nuclear bZIP transcription factor that binds CRE-like motifs and acts via partner-dependent dimerization to remodel transcriptional programs across stress, immunity, metabolism, and cell fate."