Annotation inferences using phylogenetic trees
Combined Automated Annotation using Multiple IEA Methods
A BMP homolog acts as a dose-dependent regulator of body size and male tail patterning in Caenorhabditis elegans.
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DBL-1 identified as C. elegans BMP homolog
"We cloned the dbl-1 gene, a C. elegans homolog of Drosophila decapentaplegic and vertebrate BMP genes"
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Loss-of-function causes small body size and male tail defects
"Loss-of-function mutations in dbl-1 cause markedly reduced body size and defective male copulatory structures"
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Overexpression causes large body size
"Conversely, dbl-1 overexpression causes markedly increased body size"
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Signals through Smad pathway
"Evidence from genetic interactions indicates that these effects are mediated by a Smad signaling pathway, for which DBL-1 is a previously unidentified ligand"
Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family.
Hypodermal expression of Caenorhabditis elegans TGF-beta type I receptor SMA-6 is essential for the growth and maintenance of body length.
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DBL-1 signals through SMA-6 receptor in hypodermis
"One of these pathways regulates body length and is composed of the ligand DBL-1, serine/threonine protein kinase receptors SMA-6 and DAF-4"
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Hypodermal expression essential for body size
"hypodermal expression of SMA-6 is necessary and sufficient for the growth and maintenance of body length"
Increased or decreased levels of Caenorhabditis elegans lon-3, a gene encoding a collagen, cause reciprocal changes in body length.
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dbl-1 mutations affect hypodermal endoreduplication
"loss-of-function mutations in dbl-1 and lon-1, respectively, cause a decrease or increase in the ploidy of nuclei in the hypodermal syncytial cell, hyp7"
lon-1 regulates Caenorhabditis elegans body size downstream of the dbl-1 TGF beta signaling pathway.
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lon-1 identified as downstream target of DBL-1 pathway
"lon-1 lies downstream of the Sma/Mab signaling cascade"
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lon-1 mRNA negatively regulated by DBL-1 signaling
"lon-1 mRNA levels are up-regulated in sma-6-null mutant animals"
Inducible antibacterial defense system in C. elegans.
The expression of TGFbeta signal transducers in the hypodermis regulates body size in C. elegans.
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DBL-1 expressed in neurons, signals to hypodermis
"As dbl-1 is expressed primarily in the nervous system, these results suggest a model in which postembryonic growth of hypodermal cells is regulated by TGFbeta-related signaling from the nervous system to the hypodermis"
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Affects cell size rather than cell number
"different tissues are reduced in size by different proportions, with hypodermal blast cell size most closely proportional to body size"
Cyclic GMP-dependent protein kinase EGL-4 controls body size and lifespan in C elegans.
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DBL-1 pathway regulates body size downstream of cGMP-EGL-4 signaling
"Experiments on genetic interaction suggest that the cGMP-EGL-4 signaling pathway represses body size and lifespan through DBL-1/TGF-beta and insulin pathways, respectively"
Genetic screen for small body size mutants in C. elegans reveals many TGFbeta pathway components.
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dbl-1 identified in screen for small body size
"Among 34 Small mutants, many mutations disrupt genes encoding recognizable components of the TGFbeta pathway: DBL-1 ligand"
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Also affects male tail morphogenesis
"Four of these 11 genes, sma-9, sma-14, sma-16, and sma-20 affect male tail morphogenesis as well as body size"
C. elegans serine-threonine kinase KIN-29 modulates TGFbeta signaling and regulates body size formation.
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KIN-29 acts downstream of dbl-1 in growth pathway
"These data suggest that kin-29 genetically interacts with Sma/Mab pathway signaling downstream of dbl-1 but upstream of lon-1"
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Epistasis places dbl-1 upstream of pathway targets
"kin-29 is able to suppress the long mutant phenotype generated by animals over-expressing the ligand dbl-1"
Glypican LON-2 is a conserved negative regulator of BMP-like signaling in Caenorhabditis elegans.
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LON-2 binds DBL-1 to attenuate signaling
"We propose that LON-2 binding to DBL-1 negatively regulates this pathway in C. elegans by attenuating ligand-receptor interactions"
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Acts upstream of dbl-1 genetically
"lon-2 acts genetically upstream of the BMP-like gene dbl-1"
Specificity and complexity of the Caenorhabditis elegans innate immune response.
A conserved Toll-like receptor is required for Caenorhabditis elegans innate immunity.
Regulation of rnt-1 expression mediated by the opposing effects of BRO-1 and DBL-1 in the nematode Caenorhabditis elegans.
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DBL-1 positively regulates rnt-1 gene expression
"we found that the TGFbeta homolog, DBL-1, was required for counteracting the repressive activity of BRO-1 at postembryonic stages"
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Opposes BRO-1-mediated repression
"ectopic expression of DBL-1 induced transcription of rnt-1 in the lateral hypodermis and other tissues even at the postembryonic stages"
Neuroimmune regulation of antimicrobial peptide expression by a noncanonical TGF-beta signaling pathway in Caenorhabditis elegans epidermis.
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Neuronal DBL-1 promotes antimicrobial peptide expression in epidermis
"neuronal expression of the transforming growth factor-beta homolog DBL-1 promoted cnc-2 expression in the epidermis in a dose-dependent paracrine way"
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Functions in antifungal defense
"The caenacin (cnc) genes enhanced survival after fungal infection"
DBL-1, a TGF-β, is essential for Caenorhabditis elegans aversive olfactory learning.
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DBL-1 required for aversive learning of pathogenic bacteria
"DBL-1, a Caenorhabditis elegans TGF-beta homolog known to control body morphology and immunity, is essential for aversive olfactory learning of potentially harmful bacteria food"
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Expressed in AVA command interneurons
"DBL-1 generated by the AVA command interneurons, which are critical for sensorimotor responses, regulates aversive olfactory learning"
CEH-28 activates dbl-1 expression and TGF-β signaling in the C. elegans M4 neuron.
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dbl-1 expressed in M4 neuron
"dbl-1 is expressed in M4 and a subset of other neurons"
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Regulates gland cell morphology via non-Smad pathway
"both ceh-28 and dbl-1 mutants exhibit morphological defects in the g1 gland cells located adjacent to M4 in the pharynx"
Promotion of bone morphogenetic protein signaling by tetraspanins and glycosphingolipids.
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TSP-21 promotes Sma/Mab signaling
"Promotion of bone morphogenetic protein signaling by tetraspanins and glycosphingolipids"
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DBL-1 pathway affects M lineage development
"We have shown that mutations in the core components of the Sma/Mab pathway (Fig 2A) do not cause any M lineage defect on their own, but they suppress the dorsoventral patterning defects of sma-9 mutants"
Two Paralogous Tetraspanins TSP-12 and TSP-14 Function with the ADAM10 Metalloprotease SUP-17 to Promote BMP Signaling in Caenorhabditis elegans.
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Tetraspanins promote DBL-1/BMP signaling
"Here, we show that TSP-12 and TSP-14 function redundantly in BMP signaling by regulating the cell surface localization of the ADAM10"
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Function with ADAM10/SUP-17
"TSP-12 and TSP-14 function redundantly in BMP signaling by regulating the cell surface localization of the ADAM10"
Caenorhabditis elegans DBL-1/BMP Regulates Lipid Accumulation via Interaction with Insulin Signaling.
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DBL-1 regulates lipid metabolism
"Similarly, we observed a decrease in dbl-1 mutants by ∼35% compared to wild type"
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Acts upstream of insulin signaling for lipid regulation
"genetic evidence indicates that DBL-1/BMP functions upstream of Insulin/IGF-1 Signaling in lipid metabolism"
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Both loss and gain of function reduce lipid stores
"dbl-1 overexpression strain [dbl-1(OE)] also exhibited a reduction in lipid stores"
Deep research report on dbl-1