Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

file:human/COA7/COA7-uniprot.txt

UniProtKB Q96BR5 (COA7_HUMAN) record

PMID:24333015

C1orf163/RESA1 is a novel mitochondrial intermembrane space protein connected to respiratory chain assembly.

Human C1orf163/RESA1 depletion affects respiratory complexes, with the strongest assembly defect in complex IV.

PMID:30885959

Inhibition of proteasome rescues a pathogenic variant of respiratory chain assembly factor COA7.

CHCHD4 imports COA7 as a disulfide-bonded substrate, and human biochemical/imaging experiments favor soluble IMS localization.

PMID:32296183

A reference map of the human binary protein interactome.

HuRI supplies positive binary-screen associations for five current COA7 partner assertions.

PMID:32814053

Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.

The neurodegeneration interactome supplies positive full-length or fragment yeast two-hybrid associations, rather than evidence that every pair functions in native mitochondria.

PMID:33961781

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

BioPlex supports three source-specific COA7 associations at AP-MS/co-complex scope.

PMID:34800366

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.

COA7 is included in the original high-confidence human mitochondrial proteome.

PMID:35210360

Mitochondrial COA7 is a heme-binding protein with disulfide reductase activity, which acts in the early stages of complex IV assembly.

Human COA7 combines heme binding with disulfide-reducing capacity toward SCO proteins and supports complex-IV assembly.

PMID:40205054

Multimodal cell maps as a foundation for structural and functional genomics.

The U2OS AP-MS dataset independently authenticates the three current COA7 associations cited to this source.

PMID:27683825

COA7 (C1orf163/RESA1) mutations associated with mitochondrial leukoencephalopathy and cytochrome c oxidase deficiency.

Wild-type COA7 complementation restores complex-IV assembly and activity in patient-derived fibroblasts.
The authors interpreted their trypsin-protection and fractionation experiments as predominantly matrix localization.

PMID:29718187

Mutations in COA7 cause spinocerebellar ataxia with axonal neuropathy.

Recessive COA7 variants are associated with ataxia and axonal neuropathy, with patient-dependent respiratory-complex defects.

file:human/COA7/COA7-source-evidence.json

COA7 source-record projections and public evidence locators