Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein.
Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin.
The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses.
GAKIN, a novel kinesin-like protein associates with the human homologue of the Drosophila discs large tumor suppressor in T lymphocytes.
Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102.
Association of the kinesin superfamily motor protein KIF1Balpha with postsynaptic density-95 (PSD-95), synapse-associated protein-97, and synaptic scaffolding molecule PSD-95/discs large/zona occludens-1 proteins.
Postsynaptic targeting of alternative postsynaptic density-95 isoforms by distinct mechanisms.
Selective interaction of megalin with postsynaptic density-95 (PSD-95)-like membrane-associated guanylate kinase (MAGUK) proteins.
A functional role of postsynaptic density-95-guanylate kinase-associated protein complex in regulating Shank assembly and stability to synapses.
Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia.
HIV-tat induces formation of an LRP-PSD-95- NMDAR-nNOS complex that promotes apoptosis in neurons and astrocytes.
Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis.
Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning.
Postsynaptic scaffolding molecules modulate the localization of neuroligins.
Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD.
Regulation of synaptic Rac1 activity, long-term potentiation maintenance, and learning and memory by BCR and ABR Rac GTPase-activating proteins.
DGKι regulates presynaptic release during mGluR-dependent LTD.
Protein interactome reveals converging molecular pathways among autism disorders.
Guanylate kinase domains of the MAGUK family scaffold proteins as specific phospho-protein-binding modules.
Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95.
Polarity protein complex Scribble/Lgl/Dlg and epithelial cell barriers.
The association of GPR85 with PSD-95-neuroligin complex and autism spectrum disorder: a molecular analysis.
Dysfunctional ADAM22 implicated in progressive encephalopathy with cortical atrophy and epilepsy.
Proteome-wide analysis of phospho-regulated PDZ domain interactions.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.
Quantitative fragmentomics allow affinity mapping of interactomes.
Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases.
Human postsynaptic density-95 (PSD95): location of the gene (DLG4) and possible function in nonneural as well as in neural tissues.
Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein.
Trafficking of GluR1-containing AMPA receptors
Ca2+ influx into the post-synaptic cell
kainate receptor binds glutamate
Activation of Ca-permeable Kainate receptors
RAS GEFs promote RAS nucleotide exchange
LGI1 binds ADAM22 and ADAM23
ABP1 binds SHANK proteins
PSD-95 binds NMDA receptor
SALMs 1-3 bind to PSD-95 family members
SALM1 binds NMDA receptor
Cloning and characterization of postsynaptic density 93, a nitric oxide synthase interacting protein.
Three isoforms of synaptic scaffolding molecule and their characterization. Multimerization between the isoforms and their interaction with N-methyl-D-aspartate receptors and SAP90/PSD-95-associated protein.
Identification of a novel neuroligin in humans which binds to PSD-95 and has a widespread expression.
beta 1-adrenergic receptor association with the synaptic scaffolding protein membrane-associated guanylate kinase inverted-2 (MAGI-2). Differential regulation of receptor internalization by MAGI-2 and PSD-95.
Cellular localization of the vesicular inhibitory amino acid transporter in the mouse and human retina.
Functional excitatory synapses in HEK293 cells expressing neuroligin and glutamate receptors.
Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins.
Identification of PSD-95 palmitoylating enzymes.
Mpp4 recruits Psd95 and Veli3 towards the photoreceptor synapse.
Direct interaction of post-synaptic density-95/Dlg/ZO-1 domain-containing synaptic molecule Shank3 with GluR1 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor.
Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain-specific receptor-like protein family.
Synapse-specific and developmentally regulated targeting of AMPA receptors by a family of MAGUK scaffolding proteins.
Multiple molecular interactions determine the clustering of Caspr2 and Kv1 channels in myelinated axons.
ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons.
The phosphoinositide 3-phosphatase MTMR2 interacts with PSD-95 and maintains excitatory synapses by modulating endosomal traffic.
Disrupting 5-HT(2A) receptor/PDZ protein interactions reduces hyperalgesia and enhances SSRI efficacy in neuropathic pain.
ATP induces synaptic gene expressions in cortical neurons: transduction and transcription control via P2Y1 receptors.
Association of mouse Dlg4 (PSD-95) gene deletion and human DLG4 gene variation with phenotypes relevant to autism spectrum disorders and Williams' syndrome.
PSD-95 is required to sustain the molecular organization of the postsynaptic density.
Dlg3 trafficking and apical tight junction formation is regulated by nedd4 and nedd4-2 e3 ubiquitin ligases.
PMCA2 via PSD-95 controls calcium signaling by α7-containing nicotinic acetylcholine receptors on aspiny interneurons.
PSD-95 expression controls L-DOPA dyskinesia through dopamine D1 receptor trafficking.
mSYD1A, a mammalian synapse-defective-1 protein, regulates synaptogenic signaling and vesicle docking.
A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4.
Defects in Synaptic Plasticity, Reduced NMDA-Receptor Transport, and Instability of Postsynaptic Density Proteins in Mice Lacking Microtubule-Associated Protein 1A.
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In cultured mouse hippocampal neurons, high-KCl stimulation decreases PSD-95 abundance through proteasome-sensitive degradation. The additional MAP1A-dependent increase in degradation is significant for PSD-93, not PSD-95.
Editorial Expression of Concern: Altered neuregulin 1-erbB4 signaling contributes to NMDA> receptor hypofunction in schizophrenia.
DLG4 fragmentomics: source values and interpretation