Control of axonal sprouting and dendrite branching by the Nrg-Ank complex at the neuron-glia interface.
A presynaptic giant ankyrin stabilizes the NMJ through regulation of presynaptic microtubules and transsynaptic cell adhesion.
Drosophila ankyrin 2 is required for synaptic stability.
Mapping organelle proteins and protein complexes in Drosophila melanogaster.
Glial-derived prodegenerative signaling in the Drosophila neuromuscular system.
Drosophila auditory organ genes and genetic hearing defects.
Homozygous and heterozygous disruptions of ANK3: at the crossroads of neurodevelopmental and psychiatric disorders.
Next-generation large-scale binary protein interaction network for Drosophila melanogaster.
UniProtKB Q3KN55: 697-residue Ank2-PE sequence and features
FlyBase FBpp0292239: Dmel Ank2-PE polypeptide report
The Ankyrin Repeat Domain Controls Presynaptic Localization of Drosophila Ankyrin2 and Is Essential for Synaptic Stability.
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Presynaptic targeting depends on specific ankyrin-repeat subdomains in the giant isoforms; it is not an automatic consequence of an ankyrin-repeat domain.
"We show that specific subdomains control synaptic but not axonal localization of Ank2-L."
Ank2-PE versus giant Ank2 isoforms: re-review sequence mapping
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Q3KN55 residues 159-667 are identical to giant Ank2 residues 9-517 and carry 13 of the 21 ANK repeats annotated on the giant isoforms; Q3KN55 lacks all giant-isoform sequence beyond residue 517.
"Of the 21 UniProt ANK repeat features on M9MRX4 and on Q7KU92, 13 lie fully inside the block shared with Q3KN55."
Falcon deep research: Drosophila Ank2 (Q3KN55)
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Experimental evidence is at the Ank2 locus and Ank2-L/XL level; no retrieved paper identifies the Q3KN55 product.
"Assignment to the specific Q3KN55/RE55168p sequence is less certain because the accession was not used to identify experimental constructs in the retrieved papers."
FlyBase gene description for Ank2 (DROME)