IDH2 (YOR136W, P28241) notes

• Catalytic subunit of NAD-IDH PMID:11042198; IDH2 site substitutions cut Vmax 30->300-fold PMID:11714283.
• Hetero-octamer with Idh1 PMID:16884682; structures PMID:18256028.
• Matrix enzyme [UniProt:P28241 "SUBCELLULAR LOCATION: Mitochondrion matrix"]; presequence-dependent import PMID:8626605.
• Required for isocitrate/citrate-driven respiration PMID:2198251 and growth on acetate/glycerol PMID:11714283.
• glutamate biosynthesis TAS (review PMID:9175438) kept non-core: NAD-IDH supplies 2-oxoglutarate but does not catalyse a glutamate-synthesis step; NADP-IDHs (Idp1/2/3) also supply 2-OG.