Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara.
Combined Automated Annotation using Multiple IEA Methods.
DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci.
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DNMT1 forms a complex with HDAC2 and DMAP1 at replication foci
"DNMT1, can also establish a repressive transcription complex. The non-catalytic amino terminus of DNMT1 binds to HDAC2 and a new protein, DMAP1 (for DNMT1 associated protein)"
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The complex mediates transcriptional repression during S-phase
"DMAP1 is targeted to replication foci through interaction with the far N terminus of DNMT1 throughout S phase, whereas HDAC2 joins DNMT1 and DMAP1 only during late S phase"
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DMAP1 acts as a co-repressor linking DNA methylation to histone deacetylation
"DMAP1 has intrinsic transcription repressive activity, and binds to the transcriptional co-repressor TSG101"
Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins.
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DNMT1 identified as a 14-3-3 binding protein
"proteins that bind to 14-3-3s during interphase and mitosis"
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Interaction may regulate DNMT1 subcellular localization and stability
"14-3-3 proteins regulate the cell division cycle"
The Polycomb group protein EZH2 directly controls DNA methylation.
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EZH2 directly interacts with DNMT1
"The Polycomb group protein EZH2 directly controls DNA methylation"
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EZH2 is required for DNA methylation of EZH2-target promoters
"EZH2 directly controls DNA methylation"
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Links Polycomb-mediated histone methylation to DNA methylation
"The Polycomb group protein EZH2 directly controls DNA methylation"
Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins.
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DNMT1 protein levels vary throughout the cell cycle
"Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins"
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DNMT1 accumulates during S-phase coinciding with DNA replication
"cell-cycle dependence of nuclear proteins"
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Nuclear localization is cell cycle-dependent
"widespread cell-cycle dependence of nuclear proteins"
Recruitment of the de novo DNA methyltransferase Dnmt3a by Kaposi's sarcoma-associated herpesvirus LANA.
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DNMT1 interacts with DNMT3A
"Recruitment of the de novo DNA methyltransferase Dnmt3a by Kaposi's sarcoma-associated herpesvirus LANA"
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KSHV LANA recruits both DNMT1 and DNMT3A for viral genome methylation
"Recruitment of the de novo DNA methyltransferase Dnmt3a by Kaposi's"
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Demonstrates cooperation between maintenance and de novo methyltransferases
"Recruitment of the de novo DNA methyltransferase Dnmt3a"
UHRF1 plays a role in maintaining DNA methylation in mammalian cells.
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UHRF1 is essential for maintaining DNA methylation
"is required for maintaining DNA methylation"
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UHRF1 recruits DNMT1 to hemimethylated CpG sites
"the SRA (SET and RING associated) domain, that shows strong preferential binding to hemimethylated CG sites"
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Depletion of UHRF1 causes global DNA hypomethylation similar to DNMT1 loss
"UHRF1 may help recruit DNMT1 to hemimethylated DNA to facilitate faithful maintenance of DNA methylation"
The interaction of the SRA domain of ICBP90 with a novel domain of DNMT1 is involved in the regulation of VEGF gene expression.
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The SRA domain of UHRF1/ICBP90 interacts with DNMT1
"The interaction of the SRA domain of ICBP90 with a novel domain of DNMT1 is involved in the regulation"
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This interaction regulates VEGF gene expression through promoter methylation
"The interaction of the SRA domain of ICBP90 with a novel domain of DNMT1 is involved in the regulation of VEGF gene expression"
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UHRF1 targets DNMT1 to specific genomic loci
"The interaction of the SRA domain of ICBP90 with a novel domain of DNMT1"
RIP140 directs histone and DNA methylation to silence Ucp1 expression in white adipocytes.
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RIP140 recruits DNMT1 to the Ucp1 promoter
"RIP140 directs histone and DNA methylation to silence Ucp1 expression"
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DNMT1-RIP140 interaction silences thermogenic gene expression in white adipocytes
"RIP140 directs histone and DNA methylation to silence Ucp1 expression in white adipocytes"
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Links transcriptional corepression to DNA methylation in adipocyte differentiation
"RIP140 directs histone and DNA methylation to silence Ucp1 expression"
DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation.
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DNMT1 and DNMT3B can paradoxically activate gene expression
"DNA methyltransferase 1 and 3B activate BAG-1 expression"
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DNMTs recruit CTCFL/BORIS to activate BAG-1 expression
"DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS"
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Demonstrates non-canonical gene activation role for DNMTs
"DNA methyltransferase 1 and 3B activate BAG-1 expression"
CXXC domain of human DNMT1 is essential for enzymatic activity.
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The CXXC domain is essential for DNMT1 methyltransferase activity
"Both point mutant and DNMT1 (DeltaCXXC) enzyme displayed significant reduction in catalytic activity, confirming that this domain is crucial for enzymatic activity"
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CXXC domain preferentially binds unmethylated CpG dinucleotides
"We have demonstrated that the CXXC region (C is cysteine; X is any amino acid) of DNMT1 bound specifically to unmethylated CpG dinucleotides"
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Deletion of CXXC domain abolishes enzymatic activity despite intact catalytic domain
"the CXXC domain encompassing the amino terminus region of DNMT1 cooperates with the catalytic domain for DNA methyltransferase activity"
Regulation of DNMT1 stability through SET7-mediated lysine methylation in mammalian cells.
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SET7 methylates DNMT1 at lysine 142
"SET7-mediated lysine methylation"
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Lysine methylation promotes DNMT1 proteasomal degradation
"Regulation of DNMT1 stability through SET7-mediated lysine methylation"
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SET7-mediated methylation regulates DNMT1 protein stability and cellular methylation levels
"Regulation of DNMT1 stability through SET7-mediated lysine methylation"
SUMOylation enhances DNA methyltransferase 1 activity.
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DNMT1 is modified by SUMO at multiple lysine residues
"SUMOylation enhances DNA methyltransferase 1 activity"
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SUMOylation enhances DNMT1 methyltransferase activity
"SUMOylation enhances DNA methyltransferase 1 activity"
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SUMO modification increases DNMT1 protein stability
"SUMOylation enhances DNA methyltransferase 1 activity"
Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells.
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UHRF1/Np95 bridges DNMT1 with DNMT3A and DNMT3B
"Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b"
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Complex formation coordinates maintenance and de novo methylation
"Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b"
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Essential for silencing viral CMV promoter in ES cells
"mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells"
BRCA1 affects global DNA methylation through regulation of DNMT1.
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BRCA1 regulates DNMT1 expression and stability
"BRCA1 affects global DNA methylation through regulation of DNMT1"
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BRCA1 loss leads to DNMT1 overexpression and hypermethylation
"BRCA1 affects global DNA methylation through regulation of DNMT1"
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Links BRCA1 tumor suppressor function to DNA methylation control
"BRCA1 affects global DNA methylation through regulation of DNMT1"
A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability.
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AKT1 phosphorylates DNMT1 at Ser143, stabilizing the protein
"phosphorylated DNMT1 is more stable than methylated DNMT1"
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SET7 methylates adjacent Lys142, promoting degradation
"A methylation and phosphorylation switch between an adjacent lysine and serine"
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Methylation-phosphorylation switch regulates DNMT1 stability
"A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability"
Protein interactome reveals converging molecular pathways among autism disorders.
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DNMT1 identified in autism-associated protein interaction network
"Protein interactome reveals converging molecular pathways among autism disorders"
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Suggests epigenetic dysregulation in autism spectrum disorders
"Protein interactome reveals converging molecular pathways among autism disorders"
The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1.
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USP7 forms complex with DNMT1 and UHRF1
"The USP7/Dnmt1 complex stimulates the DNA methylation activity"
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USP7 stimulates both maintenance and de novo methylation activity of DNMT1
"USP7 stimulated both the maintenance and de novo DNA methylation activity of Dnmt1 in vitro"
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USP7 deubiquitinates and stabilizes UHRF1
"USP7 regulates the stability of UHRF1"
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Complex co-localizes at silenced methylated genes
"Dnmt1, UHRF1 and USP7 co-localized on silenced, methylated genes in vivo"
SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities.
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SIRT1 deacetylates DNMT1 at multiple lysine residues
"SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein"
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Deacetylation affects DNMT1 enzymatic activity
"SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities"
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Links NAD+-dependent signaling to DNA methylation regulation
"SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein"
Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands.
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Oxidative stress recruits DNMT1-SIRT1-Polycomb complex to CpG islands
"Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands"
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Complex mediates aberrant hypermethylation under oxidative stress
"Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands"
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Links oxidative damage to epigenetic silencing in cancer
"Oxidative damage targets complexes containing DNA methyltransferases"
Methyllysine reader plant homeodomain (PHD) finger protein 20-like 1 (PHF20L1) antagonizes DNA (cytosine-5) methyltransferase 1 (DNMT1) proteasomal degradation.
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PHF20L1 recognizes methylated lysines on DNMT1
"Methyllysine reader plant homeodomain (PHD) finger protein 20-like 1 (PHF20L1)"
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PHF20L1 binding protects DNMT1 from proteasomal degradation
"Methyllysine reader plant homeodomain (PHD) finger protein 20-like 1 (PHF20L1) antagonizes DNA (cytosine-5) methyltransferase 1 (DNMT1) proteasomal degradation"
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Methyl-lysine reader proteins regulate DNMT1 stability
"Methyllysine reader plant homeodomain (PHD) finger protein 20-like 1 (PHF20L1) antagonizes DNA (cytosine-5) methyltransferase 1 (DNMT1) proteasomal degradation"
A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype.
Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.
A Protein Interaction between β-Catenin and Dnmt1 Regulates Wnt Signaling and DNA Methylation in Colorectal Cancer Cells.
MiR-140-5p regulates hypoxia-mediated human pulmonary artery smooth muscle cell proliferation, apoptosis and differentiation by targeting Dnmt1 and promoting SOD2 expression.
Enhancing the Cytotoxic Effects of PARP Inhibitors with DNA Demethylating Agents - A Potential Therapy for Cancer.
Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4(DCAF5) ubiquitin ligase.
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L3MBTL3 recognizes methylated DNMT1 for degradation
"Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3"
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CRL4(DCAF5) ubiquitin ligase targets methylated DNMT1
"Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4(DCAF5) ubiquitin ligase"
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Methylation-dependent proteolytic regulation of DNMT1
"Methylated DNMT1 and E2F1 are targeted for proteolysis"
The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically.
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EGFR-ZNF263 pathway recruits DNMT1 for gene silencing
"The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically"
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DNMT1 mediates SIX3 promoter hypermethylation in glioblastoma
"The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically"
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Links growth factor signaling to epigenetic repression in cancer
"The EGFR-ZNF263 signaling axis silences SIX3"
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
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DNMT1 detected in mitochondrial proteome studies
"Quantitative high-confidence human mitochondrial proteome"
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Suggests potential mitochondrial DNA methylation role
"Quantitative high-confidence human mitochondrial proteome and its dynamics"
OpenCell: Endogenous tagging for the cartography of human cellular organization.
New 5' regions of the murine and human genes for DNA (cytosine-5)-methyltransferase.
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Characterization of DNMT1 gene structure and regulatory regions
"New 5' regions of the murine and human genes for DNA (cytosine-5)-methyltransferase"
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Identification of alternative promoters and 5' regions
"New 5' regions of the murine and human genes for DNA (cytosine-5)-methyltransferase"
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Early molecular characterization of human DNMT1 gene
"New 5' regions of the murine and human genes for DNA (cytosine-5)-methyltransferase"
PRC2 recruits DNA methyltransferases
DNMT1,3A,3B:PRC2 methylates cytosine and histone H3
SUMOyation of DNMT1 with SUMO1
The GSDME gene promoter is hypermethylated
AcK685 p-Y705, S727 STAT3 dimer and DNMT1 bind IL2RG gene
STAT3, DNMT1 and HDAC1 bind PTPN6 gene
Translation of DNMT1 mRNA is repressed by miR-21
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miR-21 targets DNMT1 mRNA for translational repression
"Translation of DNMT1 mRNA is repressed by miR-21"
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Bidirectional regulatory loop between DNMT1 and miR-21
"Translation of DNMT1 mRNA is repressed by miR-21"
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Post-transcriptional control of DNMT1 levels
"Translation of DNMT1 mRNA is repressed by miR-21"
Deep research on DNMT1 function