Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000044

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000108

Automatic assignment of GO terms using logical inference, based on on inter-ontology links

PMID:20562859

Network organization of the human autophagy system.

Large-scale autophagy interaction network places ATG2A in autophagy-associated interaction context.

"a network of 751 interactions among 409 candidate interacting proteins"

PMID:28561066

WIPI3 and WIPI4 beta-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy.

WIPI4-ATG2 translocates to nascent autophagosomes.

"WIPI4-ATG2 is released from a WIPI4-ATG2/AMPK-ULK1 complex and translocates to nascent autophagosomes"

PMID:30952800

ATG2 transports lipids to promote autophagosome biogenesis.

ATG2A transfers glycerophospholipids and supports autophagosome biogenesis.

"ATG2A can bind tens of glycerophospholipids at once and transfers lipids robustly in vitro"
ATG2A acts at ER-autophagosome contact sites.

"operating at the ER-autophagosome interface"

PMID:31271352

The autophagic membrane tether ATG2A transfers lipids between membranes.

Human ATG2A is a lipid transfer protein.

"human ATG2A is a lipid transfer protein"
ATG2-WIPI complex acts between ER and phagophore edge.

"we place the ATG2-WIPI complex between the ER and the phagophore edge"

PMID:31412244

TOM40 Targets Atg2 to Mitochondria-Associated ER Membranes for Phagophore Expansion.

ATG2A/B loss impairs phagophore expansion.

"mammalian Atg2A/B functions at the membrane expansion step during autophagosome biogenesis"
Atg2A interacts with ATG9A at mitochondria-associated ER membranes.

"Atg2A directly interacts with Atg9A at the MAM to promote phagophore growth"

PMID:32296183

A reference map of the human binary protein interactome.

Binary interactome evidence is generic interaction context.

"A reference map of the human binary protein interactome"

PMID:32483132

Multi-site-mediated entwining of the linear WIR-motif around WIPI beta-propellers for autophagy.

WIPI proteins bind the ATG2A WIR motif and support ATG2A-mediated autophagy.

"WIPI4 forms a complex with ATG2A/B"

PMID:39174844

Structural basis for lipid transfer by the ATG2A-ATG9A complex.

Structural data support ATG2A-ATG9A/WIPI4 lipid-transfer assemblies.

"Structural basis for lipid transfer by the ATG2A-ATG9A complex"

PMID:38622126

ANKFY1 bridges ATG2A-mediated lipid transfer from endosomes to phagophores.

ANKFY1 is an endosome-localized, FYVE-domain ATG2A-binding protein that binds PI3P and enhances ATG2A-mediated lipid transfer between PI3P-containing liposomes, supporting endosome-to-phagophore lipid donation; ANKFY1 depletion phenocopies ATG2A/B loss.

PMID:37938170

ATG9B is a tissue-specific homotrimeric lipid scramblase that can compensate for ATG9A.

ATG9B is a tissue-specific homotrimeric lipid scramblase that can compensate for ATG9A and can form a heteromeric complex with ATG2A, consistent with ATG2A lipid transfer being coupled to ATG9-family scramblase activity.

PMID:37796195

Lysosome damage triggers direct ATG8 conjugation and ATG2 engagement via non-canonical autophagy.

Lysosome damage induces non-canonical autophagy (CASM) and promotes ATG2/ATG8 engagement via an ATG2 LIR-dependent mode; the robustly demonstrated interaction was ATG2B-LC3A, with a proposed role in lysosome repair (ATG2A-specific contribution inferred rather than directly established).

PMID:38294121

Exploring the ATG9A interactome uncovers interaction with VPS13A.

ATG9A acts as a lipid scramblase whose function is thought to require interaction with the lipid transfer protein ATG2A; ATG9A and ATG2A are proposed to function together to expand the growing autophagosome, and ATG9A forms a distinct complex with VPS13A separate from the ATG9A-ATG2A complex.

file:human/ATG2A/ATG2A-uniprot.txt

UniProtKB record for human ATG2A

UniProt summarizes ATG2A as a lipid transfer protein involved in autophagosome assembly.

"Lipid transfer protein involved in autophagosome assembly"

file:human/ATG2A/ATG2A-goa.tsv

GOA annotations fetched for human ATG2A

file:projects/PROTEOSTASIS/mappings/autophagy_lysosome_pathway.yaml

Proteostasis Network autophagy-lysosome pathway mappings

PN mapping treats the ATG2-WIPI bucket as the ATG2-ATG18 complex.

"The GO ATG2-ATG18 complex term is the closest component-level target."

file:projects/PROTEOSTASIS/reports/pn_projection/pn_projected_candidate_additions.tsv

Proteostasis Network projected candidate GO additions

ATG2A was projected to GO:0062079 ATG2-ATG18 complex.

"ATG2A was projected to GO:0062079 ATG2-ATG18 complex in the PN candidate additions table."

PMID:27498190

Phosphatidylinositol-3-phosphate regulates response of cells to proteotoxic stress.

file:human/ATG2A/ATG2A-hypotheses/function-hypothesis-go-0034727/openscientist.md

OpenScientist assessment of ATG2A piecemeal nuclear microautophagy