Uaf1 review notes

Accession: Q1LZ08. Planned FlyBase gene-group module (not yet committed to modules/ on main): dmel_usp46_deubiquitinase_complex.

Literature journal

• Complex and Wg role: PMID:37798281
• Mechanism: PMID:37798281; activators PMID:37798281; PMID:37798281.
• Notch (Usp12-46): PMID:22778262.

Decisions (shared across the three subunits)

• GO:1905368 peptidase complex, GO:0090263 positive regulation of canonical Wnt signaling and GO:2000059 negative regulation of ubiquitin-dependent catabolism: ACCEPT for all subunits (no more specific complex term exists in GO).
• Uaf1/Wdr20 core MF GO:0035800 deubiquitinase activator activity (own), contributes_to GO:0004843; Usp12-46 core MF GO:0004843 (own catalytic).
• Usp12-46: GO:0101005 -> MODIFY to GO:0004843; GO:0031647 -> MODIFY to GO:0050821 protein stabilization.
• Uaf1 ubiquitin binding (yeast-donor IBA/ISS) and DSB repair (IBA) kept as non-core.

Deep research (falcon, added after the initial review)

The falcon deep-research run finished after the initial commit and is now in Uaf1-deep-research-falcon.md. Its synthesis is consistent with the annotation decisions above; no review actions were changed.