Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
IFT-81 and IFT-74 are required for intraflagellar transport in C. elegans.
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IFT-74 interacts and colocalizes with IFT-81; ift-74 mutants phenocopy ift-81 with mild ciliogenesis defects and disrupted IFT.
"ift-81 and ift-74 mutants similarly exhibited weak anomalies in cilia formation and obvious disruptions of transport in mature cilia"
Dynein-Driven Retrograde Intraflagellar Transport Is Triphasic in C. elegans Sensory Cilia.
DYF-5/MAK-dependent phosphorylation promotes ciliary tubulin unloading.
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DYF-5 phosphorylates the IFT-74 N-terminal tubulin-binding region, reducing IFT-74/81 tubulin affinity about sixfold and promoting tubulin unloading.
"the ciliary kinase DYF-5/MAK phosphorylates multiple sites within the tubulin-binding module of IFT-74, reducing the tubulin-binding affinity of IFT-74/81 approximately sixfold"
Molecular basis of tubulin transport within the cilium by IFT74 and IFT81.
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IFT74 and IFT81 form a tubulin-binding module (IFT81 CH domain plus the basic IFT74 N-terminus).
"the two core IFT proteins IFT74 and IFT81 form a tubulin-binding module and mapped the interaction to a calponin homology domain of IFT81 and a highly basic domain in IFT74"
The IFT20 homolog in Caenorhabditis elegans is required for ciliogenesis and cilia-mediated behavior.