Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
A microscopy-based CRISPR screening platform enables organellar functional genomics and illuminates ciliary biology.
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TZMP1 knockout abolishes ciliogenesis in RPE1 cells; rescued by sgRNA-resistant transgene.
"SMIM27 KO cells exhibited a severe loss of cilia labeled by Arl13b or polyglutamylated tubulin, and these defects were fully rescued by an sgRNA-resistant SMIM27-2xMyc transgene"
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TZMP1 localizes to the ciliary transition zone and co-purifies with the MKS complex.
"Thus, SMIM27 is a transition zone microprotein component of the MKS complex, and we propose the revised name TZMP1."
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Xenopus orthologue required for ciliogenesis, ciliary motility and left-right patterning.
"smim27/tzmp1 is required for ciliogenesis, ciliary motility, and cilia-dependent tissue patterning in X. tropicalis"
Pervasive functional translation of noncanonical human open reading frames.
Vitamin D receptor upregulates lncRNA TOPORS-AS1 which inhibits the Wnt/β-catenin pathway and associates with favorable prognosis of ovarian cancer.