Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on curation of immunofluorescence data
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Gene Ontology annotation of human sequence-specific DNA binding transcription factors (DbTFs) based on the TFClass database
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex.
The hsp90 chaperone complex regulates intracellular localization of the dioxin receptor.
Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors.
Role of the aryl hydrocarbon receptor in cell cycle regulation.
Induced alpha-helix structure in the aryl hydrocarbon receptor transactivation domain modulates protein-protein interactions.
Constitutive activation and environmental chemical induction of the aryl hydrocarbon receptor/transcription factor in activated human B lymphocytes.
Regulation of transactivation function of the aryl hydrocarbon receptor by the Epstein-Barr virus-encoded EBNA-3 protein.
Phosphodiesterase 2A forms a complex with the co-chaperone XAP2 and regulates nuclear translocation of the aryl hydrocarbon receptor.
The aryl hydrocarbon receptor: a perspective on potential roles in the immune system.
2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation.
-
TIPARP directly interacts with and represses AHR, providing feedback regulation and evidence for AHR proteolytic degradation.
"TiPARP and AHR co-localized in the nucleus, directly interacted"
Architecture of the human interactome defines protein communities and disease networks.
Structural Basis for Aryl Hydrocarbon Receptor-Mediated Gene Activation.
Microbiota-Derived Indole Metabolites Promote Human and Murine Intestinal Homeostasis through Regulation of Interleukin-10 Receptor.
IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression.
Endogenous Indole Pyruvate Pathway for Tryptophan Metabolism Mediated by IL4I1.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
The role of DNA-binding and ARNT dimerization on the nucleo-cytoplasmic translocation of the aryl hydrocarbon receptor.
-
AHR is predominantly cytoplasmic and ligand activation stabilizes nuclear accumulation independent of ARNT or DNA binding.
"predominantly located in the cytoplasm, while activation depends on its nuclear translocation"
Structural basis for the ligand-dependent activation of heterodimeric AHR-ARNT complex.
-
Crystal structures of AHR-ARNT-DNA complexes bound to six AHR ligands (tapinarof, FICZ, benzo[a]pyrene, beta-naphthoflavone, indigo, indirubin) reveal an unconventional assembly with intimate PAS-B to PAS-B association between AHR and ARNT.
-
The AHR PAS-B domain is the principal ligand-binding pocket, using eight conserved residues that dynamically rearrange to accommodate diverse ligands via hydrophobic and pi-pi interactions.
-
Ligand binding drives a structural transition of an AHR segment from chaperone engagement to ARNT-heterodimer stabilization, generating the transcriptionally competent AHR:ARNT DNA-bound complex.
The aryl hydrocarbon receptor: a rehabilitated target for therapeutic immune modulation.
-
AHR is a ligand-activated transcription factor that functions as a physiological regulator of both innate and adaptive immunity, modulated by diet, commensal flora, and metabolism in autoimmunity, cancer, and infection.
-
The AHR-activating drug tapinarof was approved for treatment of psoriasis, and AHR-targeting therapeutics are in clinical trials for inflammatory diseases, cancer, and infection, establishing AHR as a tractable therapeutic target.
Dioxin binding activities of polymorphic forms of mouse and human arylhydrocarbon receptors.
Cloning and expression of a human Ah receptor cDNA.
Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway.
Human Ah receptor (AHR) gene: localization to 7p15 and suggestive correlation of polymorphism with CYP1A1 inducibility.
Transcriptionally active heterodimer formation of an Arnt-like PAS protein, Arnt3, with HIF-1a, HLF, and clock.
AHR:2xHSP90:AIP:PTGES3 binds TCDD
Aryl hydrocarbon receptor signalling
AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm
AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates
Proteostasis PN projected candidate additions
Proteostasis PN mapping scrutiny report
Proteostasis PN ubiquitin proteasome system mapping set