Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor.

A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits.

Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily.

Interaction of the corepressor Alien with DAX-1 is abrogated by mutations of DAX-1 involved in adrenal hypoplasia congenita.

Hepatopoietin interacts directly with COP9 signalosome and regulates AP-1 activity.

Detection and identification of transcription factors as interaction partners of alien in vivo.

Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry.

Symmetrical modularity of the COP9 signalosome complex suggests its multifunctionality.

Defining the human deubiquitinating enzyme interaction landscape.

Structural insights into the COP9 signalosome and its common architecture with the 26S proteasome lid and eIF3.

Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics.

A physical interaction network of dengue virus and human proteins.

The corepressor activity of Alien is controlled by CREB-binding protein/p300.

Dynamic regulation of the COP9 signalosome in response to DNA damage.

Crystal structure of the human COP9 signalosome.

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

A reference map of the human binary protein interactome.

Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

Multimodal cell maps as a foundation for structural and functional genomics.

XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site

ERCC8 (CSA) binds stalled RNA Pol II

NEDD8-STON binds TOR1 hexamer and COP9 complex

COP9 and TOR1 deneddylate STON2

COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes

COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex